Materials or Biomaterials?

Sd, Bruck

doi:10.1177/039139889001300803

Cited by 3 publications

(2 citation statements)

References 1 publication

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“…32 In addition, calcification of biomaterials is another key factor to be considered, particularly if the materials undergo repeated flexing. 37 Approaches to the prevention of calcification, such as localized sustained release of calcium chelating agents, are being studied. 38,39 In summary, the key factors that need to be considered when designing the "ideal" vascular graft are mismatch of material properties between the host artery and the graft and surface thrombosis of vascular grafts.…”

Section: Blood-interfacing Implants: Vascular Graftsmentioning

confidence: 99%

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Biomedical Application of Commercial Polymers and Novel Polyisobutylene-Based Thermoplastic Elastomers for Soft Tissue Replacement

2004

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Novel polyisobutylene-based thermoplastic elastomers are introduced as prospective implant materials for soft tissue replacement and reconstruction. In comparison, poly(ethylene terephthalate) (PET), poly(tetrafluoroethylene) (PTFE), polypropylene (PP), polyurethanes (PU), and silicones are outlined from well-established implant history as being relatively inert and biocompatible biomaterials for soft tissue replacement, especially in vascular grafts and breast implants. Some general considerations for the design and development of polymers for soft tissue replacement are reviewed from the viewpoint of material science and engineering, with special attention to synthetic materials used in vascular grafts and breast implants.

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Section: Blood-interfacing Implants: Vascular Graftsmentioning

confidence: 99%

“…In addition, calcification of biomaterials is another key factor to be considered, particularly if the materials undergo repeated flexing . Approaches to the prevention of calcification, such as localized sustained release of calcium chelating agents, are being studied. , …”

Section: Blood-interfacing Implants: Vascular Graftsmentioning

confidence: 99%

Biomedical Application of Commercial Polymers and Novel Polyisobutylene-Based Thermoplastic Elastomers for Soft Tissue Replacement

2004

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Construction of cell‐compatible layer and culture of human umbilical vascular endothelial cells on porous polystyrene membranes

Gao

Liu

et al. 2001

J of Applied Polymer Sci

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Porous polystyrene (PS) membranes with pore sizes ranged from nanometer scale to several decades' micrometers were fabricated by the thermally induced phase-separation technique, and were characterized by scanning electron microscopy (SEM). Oxidation of PS membranes by concentrated sulfuric acid induced a decrease of the carbon amount on the membrane surfaces accompanying with an increase of the oxygen amount. The hydrophilic surfaces thus constructed proved quite effective to promote endothelial cell adhesion and growth. After culturing for 4 days, a confluent endothelial cells (ECs) layer was observed on nonporous PS membrane treated previously with sulfuric acid for 15 min at 28.5°C. The observation under SEM showed that ECs on the PS membrane surfaces at the fourth day were inversely proportional to the pore size: the smaller the pore size, the larger the amount of ECs on the membrane surfaces. It is supposed that the existence of pores on the membrane surface might generate some disadvantageous resistance to the spreading of cells.

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Morphological Response of the Peritoneum and Spleen to Intraperitoneal Biomaterials

Guo¹,

Wïllén

Andersson³

et al. 1993

Int J Artif Organs

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The present study was performed to evaluate the morphological response of the peritoneum and spleen to biomaterials. Silicone elastomer, knitted dacron or rubber was implanted, respectively, into a rat's peritoneal cavity and the morphology of the peritoneum and spleen was studied at 4 hours and on the 1st, 4th, 7th and 21st day after surgery. The morphological changes were identical among groups with different implanted materials. After intraperitoneal implantation of biomaterials from 4 hours and on, an infiltration of inflammatory cells was found in the slackened edematous superficial part of the peritoneum. Also noted in the spleen were stasis, vessel dilatation and fibrin deposition. With the help of scanning electron microscopy, a marked denudation and separation of the mesothelial cells, with infiltration of inflammatory cells, were observed. Peripheral leucocytes significantly increased in number one day after intraperitoneal implantation. Three weeks after intraperitoneal implantation, the materials were completely encapsulated and the morphological aberration of the peritoneum and spleen disappeared. The findings reveal the consequence and the resolution of the host-biomaterial interaction, which could contribute to the explanation of various pathophysiological alterations, including the translocation of enteric bacteria and the development of infectious complications after intraperitoneal biomaterial implantation.

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Materials or Biomaterials?

Cited by 3 publications

References 1 publication

Biomedical Application of Commercial Polymers and Novel Polyisobutylene-Based Thermoplastic Elastomers for Soft Tissue Replacement

Biomedical Application of Commercial Polymers and Novel Polyisobutylene-Based Thermoplastic Elastomers for Soft Tissue Replacement

Construction of cell‐compatible layer and culture of human umbilical vascular endothelial cells on porous polystyrene membranes

Morphological Response of the Peritoneum and Spleen to Intraperitoneal Biomaterials

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