Although the need for addressing matching in the analysis of matched case-control studies is well established, debate remains as to the most appropriate analytic method when matching on at least one continuous factor. We compare the bias and efficiency of unadjusted and adjusted conditional logistic regression (CLR) and unconditional logistic regression (ULR) in the setting of both exact and non-exact matching. To demonstrate that case-control matching distorts the association between t…
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