2018
DOI: 10.18632/aging.101483
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Abstract: Matcha green tea (MGT) is a natural product that is currently used as a dietary supplement and may have significant anti-cancer properties. However, the molecular mechanism(s) underpinning its potential health benefits remain largely unknown. Here, we used MCF7 cells (an ER(+) human breast cancer cell line) as a model system, to systematically dissect the effects of MGT at the cellular level, via i) metabolic phenotyping and ii) unbiased proteomics analysis. Our results indicate that MGT is indeed sufficient t… Show more

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Cited by 31 publications
(22 citation statements)
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References 55 publications
(51 reference statements)
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“…376 However, matcha green tea (MGT), an inhibitor of mTOR, inhibits the proliferation of breast CSCs by targeting mitochondrial metabolism, glycolysis, and multiple cell signaling pathways. 377 A link between the PI3K/ Akt/mTOR pathway and CSCs is clearly evident.…”
Section: Major Signaling Pathways In Cscsmentioning
confidence: 98%
“…376 However, matcha green tea (MGT), an inhibitor of mTOR, inhibits the proliferation of breast CSCs by targeting mitochondrial metabolism, glycolysis, and multiple cell signaling pathways. 377 A link between the PI3K/ Akt/mTOR pathway and CSCs is clearly evident.…”
Section: Major Signaling Pathways In Cscsmentioning
confidence: 98%
“…It is believed that the main antitumor mechanism of EGCG is the inhibition of metalloproteinase activity. This hypothesis has been supported by study indicating the reduction of prostate cancer metastases after oral supplementation of green tea catechins [33]. Green tea catechols were also proven to inhibit lung melanoma metastasis in animal model [35].…”
Section: Anticancer Potential Of Green Tea Catechins Based On In Vitrmentioning
confidence: 82%
“…However, under specific conditions, they may have pro-oxidative effects [32]. The control of catechins under intracellular pool of nitro-oxidative stress is mainly responsible for their anticancer properties [33]. Therefore, polyphenolic compounds that bring health-promoting properties for the body can also result in the opposite effects if very high doses of catechins are used [19].…”
Section: Catechins: Modes Of Actionmentioning
confidence: 99%
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