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Cited by 10 publications
(9 citation statements)
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References 63 publications
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“…While the parasitemia dropped below detection limit after treatment, it was observed that 10 months later more patients in the posaconazole groups had treatment failure during follow-up than in the comparative benznidazole group. Thereafter, some authors have proposed not to abandon the triazoles during Chagas disease but to find a suitable partner for combination therapy [82]. Our results suggest that this approach could be considered for HAT with an eflornithine-based combination.…”
Section: Discussionmentioning
confidence: 82%
“…While the parasitemia dropped below detection limit after treatment, it was observed that 10 months later more patients in the posaconazole groups had treatment failure during follow-up than in the comparative benznidazole group. Thereafter, some authors have proposed not to abandon the triazoles during Chagas disease but to find a suitable partner for combination therapy [82]. Our results suggest that this approach could be considered for HAT with an eflornithine-based combination.…”
Section: Discussionmentioning
confidence: 82%
“…cruzi drug discovery pipeline is well populated with CYP51 inhibitors ( Pena et al., 2015 ), which could promote de-prioritisation of this chemical class of compound. The image-based assay however could be used to screen a combination of (sub-efficacious) inhibitors such as posaconazole with other active compounds, to identify if there is a synergistic effect of compound action ( Fügi et al., 2015 ). A medicinal chemistry effort could potentially improve efficacy, dependent upon if it were an intrinsic target problem or could be overcome, as other factors such as solubility may also cause this effect.…”
Section: Discussionmentioning
confidence: 99%
“…High-throughput crossing experiments have shown that many viable S. cerevisiae gene deletion mutants possess synthetic phenotypes, i.e., growth defects that become apparent only in the absence of another nonessential gene. The concept of genetic synthetic lethality can be adopted to combination chemotherapy ( 8 , 10 12 ). The principal idea is to extrapolate from synthetic lethal gene pairs in S. cerevisiae to orthologous pairs of genes in P. falciparum , assuming that the combined inhibition of the respective gene products will produce a synergistic effect.…”
Section: Textmentioning
confidence: 99%