Mastocytosis in practice of a family doctors

Frolova, T. G.; Tereshchenkova, II; Stenkova, NF

doi:10.15407/internalmed2018.01.022

Cited by 3 publications

(2 citation statements)

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“…According to the medical literature (Pardanani, 2016; Frolova et al, 2018;Leguit et al, 2020), mastocytosis affects both adults and children. Adults experience systemic mastocytosis, which affects not only the skin, but also the spleen, liver, and bone marrow.…”

Section: Literature Reviewmentioning

confidence: 99%

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2023

Ukrainian journal of veterinary sciences

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Section: Literature Reviewmentioning

confidence: 99%

Untitled

2023

Ukrainian journal of veterinary sciences

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“…Як свідчить аналіз літературних повідомлень (Willmann et al, 2018;Tamlin et al, 2020) перебіг захворювань, за безпосередньої участі активованих ОК, у людини та в тварин має певні відмінності. За даними медичної літератури (Frieri & Quershi, 2013;Valent et al, 2015;Gülen et al, 2016;Pardanani, 2016;Frolova et al, 2018;Leguit et al, 2020) на мастоцитоз частіше хворіють діти у яких хвороба перебігає у шкірній формі (зазвичай, як пігментна кропив'янка, рідше солітарна мастоцитома) і при досягненні пубертатного віку хвороба, як правило, регресує. Водночас, серед дорослих доброякісні форми мастоцитозу трапляються рідко.…”

Section: мастоцитомаunclassified

Clinical characteristics of mastocytoma in dogs

2020

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According to foreign researchers, mastocytoma is one of the most common (7-12 %) skin tumors in dogs. This neoplasia is caused by excessive proliferation of mast cells and characterized by a specific clinical course, unpredictable biological behavior and prognosis. Researches of clinical and morphological features of mastocytoma in geographical populations of Ukraine has not only scientific and general biological interest, but also important practical significance. The purpose of the research was to establish the frequency of spreading, the features of the clinical ostent and pathogenesis of cutaneous mastocytoma in dogs in conditions in Lviv and in the suburban zone of the regional center. The research was performed on dogs with skin tumors (n = 128), including 24 of them with mastocytoma, who came to the Department of Surgery and Clinic of Small Pets of Stepan Gzhytskyj LNUVMB during 2016–2020. The diagnosis on mastocytoma was verified by the results of physical examination and cytological examination of biopsy material of neoplasms. It was found that in the structure of oncological diseases of dogs the share of skin neoplasms was 32.16 %. Among animals with skin neoplasms, mastocytoma was diagnosed in 18.75 % of dogs aged 4 to 16 years. The highest incidence rates were found among animals aged 8 to 11 years; the median incidence was 9.5 years and fashion – 9 years. In terms of breeds, cutaneous mastocytoma was found in dogs of the breed: Rottweiler – 16.7 %, Sharpei – 12.5 %, Staffordshire Terrier – 12.5 %, Labrador – 8.3 %, Boxer – 8.3 %, Doberman – 8.3 %, chow-chow – 8.3 %. At the same time, the German Shepherd, Alabai, Spaniel, French Bulldog and Pug cases of the disease were isolated (4.2 %). Among sick animals, dogs accounted for 54.2 % and females for 45.8 %. It was found that in 41.7 % of the studied animals the rate of neoplasia was extremely rapid, because in 56.5 ± 1.91 days the tumors were doubled in size, which is evidence of significant aggressiveness of tumor growth. In 29.2 % of dogs the time of doubling the size of the primary tumor reached 122.1 ± 10.6 days, in 20.8 % of dogs the period of tumor development lasted for two years. In 8.3 % of dogs, the dynamics of neoplasia development is not clear. Sonography has shown that skin mastocytomas are usually visualized as heterogeneous, with uneven edges and fuzzy contours hypoechoic structures. Visualization of solid hypervascular foci with central type of vascularization, on the background of diffuse infiltration of neoplasia in the deeper layers of the skin and subcutaneous tissue, with a pronounced perinodular inflammatory reaction of the surrounding tissues is a sign of malignancy of the mastocytoma. The generalization of the neoplastic process in the internal organs was found, in particular the spleen, may indicate a predominance of the hematogenous route of metastasis of the mastocytoma. The obtained data complement and expand knowledge about the pathogenesis of mastocytoma in dogs, and also highlight the frequency of spreading and course features of this oncological pathology in a separate geographical population of Ukraine.

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Clinical and morphological features of mastocyte diagnosis in dogs

Kolych¹,

Hudz²,

Tarasov³

2023

Ukrainian journal of veterinary sciences

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Mastocytoma is one of the most common skin tumours in dogs. It is characterised by a specific course, unpredictable behaviour, and prognosis. This tumour is dangerous because it mimics the external signs of other neoplasms, from less-threatening lipoma to skin cancer. The purpose of the study is to conduct pathomorphological verification and classification of neoplasia in dogs diagnosed during a clinical examination and to establish the features of the morphological manifestation of the skin form of mastocytoma in them. The material for the studies was obtained by excisional biopsy during surgical interventions for skin neoplasms. The diagnosis of mastocytoma was established based on the results of a clinical examination of animals and the examination of biopsy material of neoplasms using cytological and histological research methods. It was established that the share of skin neoplasia in the structure of oncological diseases of dogs was 30.12%. Among the animals with skin neoplasia that were examined, mastocytoma was diagnosed in 17.55% of dogs aged 3 to 14 years. The highest incidence rates were established in dogs aged 7 to 12 years. Most often, skin mastocytoma was diagnosed in dogs of the following breeds: Shar Pei – 13.5%; Labrador – 9.5%; Boxer – 8.2%. Isolated cases of tumour formations were observed in animals of such breeds as: German shepherd, Spaniel, Central Asian Shepherd, and Pug. Depending on gender: males accounted for 52.2%, females – 47.8%. In 50% of the examined animals, mastocytomas developed with rapid dynamics, which indicates a substantial aggressiveness of tumour growth. Clinically, signs of dehydration and gastrointestinal disorders were detected in dogs, which indicates the development of paraneoplastic syndrome. According to the results of sonography, it was established that skin mastocytomas are visualised as heterogeneous hypoechoic structures with indistinct contours and uneven edges. Based on the results of the study, new information was obtained regarding the morphological features of the manifestation and development of mastocytes in dogs. Thus, the obtained results complement and expand knowledge about the pathogenesis of mastocytoma in dogs, the frequency of spread and features of the course of this oncological pathology in a separate geographical population of Ukraine

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Mastocytosis in practice of a family doctors

Cited by 3 publications

References 25 publications

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Clinical characteristics of mastocytoma in dogs

Clinical and morphological features of mastocyte diagnosis in dogs

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