Mastering Death: The Roles of Viral Bcl-2 in dsDNA Viruses
Chathura D. Suraweera,
Benjamin Espinoza,
Mark G. Hinds
et al.
Abstract:Proteins of the Bcl-2 family regulate cellular fate via multiple mechanisms including apoptosis, autophagy, senescence, metabolism, inflammation, redox homeostasis, and calcium flux. There are several regulated cell death (RCD) pathways, including apoptosis and autophagy, that use distinct molecular mechanisms to elicit the death response. However, the same proteins/genes may be deployed in multiple biochemical pathways. In apoptosis, Bcl-2 proteins control the integrity of the mitochondrial outer membrane (MO… Show more
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