Mast cells promote malaria infection?

Theoharides, Theoharis C.

doi:10.1016/j.clinthera.2015.03.014

Cited by 7 publications

(5 citation statements)

References 18 publications

(18 reference statements)

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“…IL-33 has been linked to autoimmune and inflammatory diseases (Theoharides et al, 2015c ), especially brain inflammation (Chakraborty et al, 2010 ) and recently AD pathogenesis (Xiong et al, 2014 ). Antigen can also act synergistically with toll-like receptors (TLR-2 and TLR-4) to produce MC cytokines (Qiao et al, 2006 ) and regulate responses to pathogens (Abraham and St John, 2010 ; Theoharides, 2015 ).…”

Section: Role Of Mast Cellsmentioning

confidence: 99%

Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin

Theoharides¹,

et al. 2015

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Brain “fog” is a constellation of symptoms that include reduced cognition, inability to concentrate and multitask, as well as loss of short and long term memory. Brain “fog” characterizes patients with autism spectrum disorders (ASDs), celiac disease, chronic fatigue syndrome, fibromyalgia, mastocytosis, and postural tachycardia syndrome (POTS), as well as “minimal cognitive impairment,” an early clinical presentation of Alzheimer's disease (AD), and other neuropsychiatric disorders. Brain “fog” may be due to inflammatory molecules, including adipocytokines and histamine released from mast cells (MCs) further stimulating microglia activation, and causing focal brain inflammation. Recent reviews have described the potential use of natural flavonoids for the treatment of neuropsychiatric and neurodegenerative diseases. The flavone luteolin has numerous useful actions that include: anti-oxidant, anti-inflammatory, microglia inhibition, neuroprotection, and memory increase. A liposomal luteolin formulation in olive fruit extract improved attention in children with ASDs and brain “fog” in mastocytosis patients. Methylated luteolin analogs with increased activity and better bioavailability could be developed into effective treatments for neuropsychiatric disorders and brain “fog.”

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Section: Role Of Mast Cellsmentioning

confidence: 99%

Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin

Theoharides¹,

et al. 2015

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“…Conversely, it had been demonstrated that MCs-derived TNF had crucial role in host defense against Plasmodium berghei ANKA ( Pb ANKA) infection in murine model (Furuta et al, 2006). Further, MCs activation stimulated by different Plasmodium species ( P. chabaudi AS or Pb ANKA) can improved or deteriorate the malaria pathogenesis, respectively (Engwerda and Kumar, 2013; Guermonprez et al, 2013; Theoharides, 2015). These studies indicated that MCs may lead to different outcomes of malaria disease severity possibly due to differences in Plasmodium species or selective release of different mediators (Theoharides et al, 2007; Lu and Huang, 2017).…”

Section: Introductionmentioning

confidence: 99%

Activation of Mast Cells Promote Plasmodium berghei ANKA Infection in Murine Model

Huang

Chen

et al. 2019

Front. Cell. Infect. Microbiol.

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Malaria, a mosquito-borne infectious disease, is a severe health problem worldwide. As reported, some anti-malarial drugs with anti-parasitic properties also block mast cells (MCs) activities. It is hypothesized that MCs activity may be correlated with the pathogenesis of malaria. Thus, the role of MCs on malarial pathogenesis and the involved physiological action and pathways need to be further investigated. This study aimed to investigate the effect of MCs activation on malaria disease severity using KunMing mice with Plasmodium berghei ANKA (PbANKA) infection treated with MCs degranulator (compound 48/80, C48/80) or MCs stabilizer (disodium cromoglycate, DSCG). PbANKA infection caused a dramatic increase in MCs density and level of MCs degranulation in cervical lymph node (CLN) and skin. Compared with infected control, C48/80 treatment had shortened survival time, increased parasitemia, exacerbated liver inflammation and CLN hyperplasia, accompanied with increase in vascular leakage and leukocyte number. The infected mice with C48/80 treatment also elevated the release of CCL2, CXCL1, and MMP-9 from MCs in CLN and skin, and TNF-α, IFN-γ, CCR2, and CXCR2 mRNA expression in CLN and liver. In contrast, the infected mice treated with DSCG showed longer survival time, lower parasitemia, improved liver inflammation and CLN hyperplasia, followed by a decline of vascular leakage and leukocyte number. Decreased MCs-derived CCL2, CXCL1, and MMP-9 from CLN and skin, mRNA expression in CLN and liver (TNF-α, IFN-γ, CCR2, and CXCR2) were also observed in infected mice with DSCG treatment. Our data indicated that MCs activation may facilitate the pathogenesis of PbANKA infection.

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“…Kenyan children with mild and severe malaria were shown to have increased plasma levels of Flt3 ligand (Flt3L) (15). Elevated serum Flt3L levels and DC expansion were found in patients infected by P. falciparum and mice with Plasmodium infection.…”

Section: Mcs In Plasmodium Spp Infectionmentioning

confidence: 99%

“…It is well known that MCs play an important role in parasitic helminth infections (13). Accumulating evidences have demonstrated that MCs have pivotal roles in parasitic protozoan diseases (14, 15); this has led us to focus on the role of MCs in the immune responses against parasitic infections including Plasmodium spp., Leishmania spp., Trypanosoma spp., and T. gondii . The main function of MCs in the aforementioned protozoa is summarized in Table 1.…”

Section: Introductionmentioning

confidence: 99%

The Roles of Mast Cells in Parasitic Protozoan Infections

Huang

2017

Front. Immunol.

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Protozoan parasites such as Plasmodium spp., Leishmania spp., Trypanosoma spp., and Toxoplasma gondii are major causes of parasitic diseases in both humans and animals. The immune system plays a critical role against protozoa, but their immune mechanism remains poorly understood. This highlights the need to investigate the function of immune cells involved in the process of parasite infections and the responses of host immune system to parasite infections. Mast cells (MCs) are known to be central players in allergy and anaphylaxis, and it has been demonstrated that MCs have crucial roles in host defense against a number of different pathogens, including parasites. To date, there are many studies that have examined the interaction of helminth-derived antigens and MCs. As one of the major effector cells, MCs also play an important role in the immune response against some parasitic protozoa, but their role in protozoan infections is, however, less well characterized. Herein, we review the current knowledge about the roles of MCs and their mediators during infections involving highly pathogenic protozoa including Plasmodium spp., Leishmania spp., Trypanosoma spp., and T. gondii. We offer a general review of the data from patients and experimental animal models infected with the aforementioned protozoa, which correlate MCs and MC-derived mediators with exacerbated inflammation and disease progression as well as protection against the parasitic infections in different circumstances. This review updates our current understanding of the roles of MCs during parasitic protozoan infections, and the participation of MCs in parasitic protozoan infections could be of a potential therapeutic target.

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Mast cells promote malaria infection?

Cited by 7 publications

References 18 publications

Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin

Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin

Activation of Mast Cells Promote Plasmodium berghei ANKA Infection in Murine Model

The Roles of Mast Cells in Parasitic Protozoan Infections

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