volume 8, issue 11, P3065-3090 2016
DOI: 10.18632/aging.101113
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Irina Tsoy Nizamutdinova, Giuseppina F. Dusio, Olga Yu. Gasheva, Hunter Skoog, Richard Tobin, Chander Peddaboina, Cynthia J. Meininger, David C. Zawieja, M. Karen Newell-Rogers, Anatoliy A. Gashev

Abstract: This study aimed to establish mechanistic links between the aging-associated changes in the functional status of mast cells and the altered responses of mesenteric tissue and mesenteric lymphatic vessels (MLVs) to acute inflammation. We used an in vivo model of acute peritoneal inflammation induced by lipopolysaccharide treatment of adult (9-month) and aged (24-month) F-344 rats. We analyzed contractility of isolated MLVs, mast cell activation, activation of nuclear factor-κB (NF-κB) without and with stabiliza…

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