Mast-cell stabilising agents to prevent exercise-induced bronchoconstriction

Sodium Cromoglycate Alone and in Combination With Montelukast on the Airway Response to Mannitol in Asthmatic Subjects

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Sodium Cromoglycate Alone and in Combination With Montelukast on the Airway Response to Mannitol in Asthmatic Subjects

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Prevention of Exercise-induced Asthma by a Fixed Combination of Disodium Cromoglycate plus Reproterol Compared with Montelukast in Young Patients

“…Germany and Spain, inhalers with fixed combinations of one of these compounds with short-acting β 2 -agonists (SABA) are available and have a substantial role in the treatment of asthma in these countries. Although a recent Cochrane review confirmed the effectiveness of MCS and in particular their combination with SABA for the prevention of exercise-induced asthma (EIA) [2], this appears to have not yet influenced current recommendations for the treatment of EIA [1]. Moreover, the Cochrane review did not respect all investigations with DSCG/reproterol (REP, CAS 54063-54-6), the combination used in our study.…”

The emerging role of transient receptor potential channels in chronic lung disease

“…mannitol) provoke bronchoconstriction and cough in asthmatics via activation of sensory nerves [71]. Consistent with a neuronal mechanism, anticholinergics produce significant protection from exercise-induced bronchospasm [72]. With nonallergic triggers we propose that the agent would directly stimulate nerves, via TRP channels, to induce bronchospasm/LAR/cough in a steroid-resistant manner, explaining the relative treatment-resistant phenotype associated with nonallergic, non-T-helper cell type 2 asthma (figure 1).…”

Sodium Cromoglycate Alone and in Combination With Montelukast on the Airway Response to Mannitol in Asthmatic Subjects

“……”

“……”

Prevention of Exercise-induced Asthma by a Fixed Combination of Disodium Cromoglycate plus Reproterol Compared with Montelukast in Young Patients

“…Germany and Spain, inhalers with fixed combinations of one of these compounds with short-acting β 2 -agonists (SABA) are available and have a substantial role in the treatment of asthma in these countries. Although a recent Cochrane review confirmed the effectiveness of MCS and in particular their combination with SABA for the prevention of exercise-induced asthma (EIA) [2], this appears to have not yet influenced current recommendations for the treatment of EIA [1]. Moreover, the Cochrane review did not respect all investigations with DSCG/reproterol (REP, CAS 54063-54-6), the combination used in our study.…”

The emerging role of transient receptor potential channels in chronic lung disease

“…mannitol) provoke bronchoconstriction and cough in asthmatics via activation of sensory nerves [71]. Consistent with a neuronal mechanism, anticholinergics produce significant protection from exercise-induced bronchospasm [72]. With nonallergic triggers we propose that the agent would directly stimulate nerves, via TRP channels, to induce bronchospasm/LAR/cough in a steroid-resistant manner, explaining the relative treatment-resistant phenotype associated with nonallergic, non-T-helper cell type 2 asthma (figure 1).…”

Sodium Cromoglycate Alone and in Combination With Montelukast on the Airway Response to Mannitol in Asthmatic Subjects

“……”

“……”

Prevention of Exercise-induced Asthma by a Fixed Combination of Disodium Cromoglycate plus Reproterol Compared with Montelukast in Young Patients

“…Germany and Spain, inhalers with fixed combinations of one of these compounds with short-acting β 2 -agonists (SABA) are available and have a substantial role in the treatment of asthma in these countries. Although a recent Cochrane review confirmed the effectiveness of MCS and in particular their combination with SABA for the prevention of exercise-induced asthma (EIA) [2], this appears to have not yet influenced current recommendations for the treatment of EIA [1]. Moreover, the Cochrane review did not respect all investigations with DSCG/reproterol (REP, CAS 54063-54-6), the combination used in our study.…”

The emerging role of transient receptor potential channels in chronic lung disease

“…mannitol) provoke bronchoconstriction and cough in asthmatics via activation of sensory nerves [71]. Consistent with a neuronal mechanism, anticholinergics produce significant protection from exercise-induced bronchospasm [72]. With nonallergic triggers we propose that the agent would directly stimulate nerves, via TRP channels, to induce bronchospasm/LAR/cough in a steroid-resistant manner, explaining the relative treatment-resistant phenotype associated with nonallergic, non-T-helper cell type 2 asthma (figure 1).…”