2005
DOI: 10.1128/jvi.79.2.1164-1179.2005
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Abstract: Avian infectious bronchitis virus (IBV) is a member of theCoronaviridae (order Nidovirales) (9), members of which are enveloped viruses with single-stranded, positive-sense RNA genomes that are 5Ј capped and 3Ј polyadenylated (30, 63). The 5Ј two-thirds of the coronavirus genome encodes the replicase gene producing two polyproteins, Rep1a and Rep1ab, the latter resulting from a Ϫ1 frameshift (7). The remaining proteins, which include the nucleoprotein (N), are expressed from a nested set of subgenomic mRNAs (s… Show more

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Cited by 120 publications
(156 citation statements)
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References 83 publications
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“…The N protein is located inside the virion, closely associated with its genome, and interacts with viral and host-cell nuclear proteins (Holmes& Williams, 1990;Cavanagh, 1995;Ignjatovic & Sapats, 2005). Important biological functions are attributed to N-phosphoprotein, including viral replication, rRNA interaction, grouping and budding of (Chen et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…The N protein is located inside the virion, closely associated with its genome, and interacts with viral and host-cell nuclear proteins (Holmes& Williams, 1990;Cavanagh, 1995;Ignjatovic & Sapats, 2005). Important biological functions are attributed to N-phosphoprotein, including viral replication, rRNA interaction, grouping and budding of (Chen et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…Surjit et al (18) provided evidence that SCoV N protein undergoes phosphorylation in cells, mainly at the serine residues. The phosphorylation residues of the TGEV, IBV, MHV A59, and SCoV N proteins have recently been identified as Ser and Thr (16,[19][20][21]. However, the putative kinase(s) responsible for N protein phosphorylation and the effects of …”
mentioning
confidence: 99%
“…The biological effects of N protein phosphorylation could influence its RNA binding activity and its subcellular localization (17)(18)(19)22). For IBV, Chen et al (19) demonstrated that phosphorylated N protein was bound to viral RNA with a higher affinity than nonviral RNA.…”
mentioning
confidence: 99%
“…45,46 The NC protein was phosphorylated proximal to RNA-binding sites in the globular region and the C-terminus of the CP. 47,48 IBV NC protein phosphorylation at the C-terminus proved to be involved in the regulation of NC protein-RNA binding and in the discrimination between viral and cellular RNAs. 48,49 Rubella virus (RuV) is an enveloped (+)-strand ssRNA virus and a member of the family Togaviridae.…”
mentioning
confidence: 99%
“…47,48 IBV NC protein phosphorylation at the C-terminus proved to be involved in the regulation of NC protein-RNA binding and in the discrimination between viral and cellular RNAs. 48,49 Rubella virus (RuV) is an enveloped (+)-strand ssRNA virus and a member of the family Togaviridae. The RuV CP is involved in RNA packaging, a regulated event that occurs on the Golgi complex membrane.…”
mentioning
confidence: 99%