Mass spectrometry in bioinorganic analytical chemistry

Łobiński, Ryszard; Schaumlöffel, Dirk; Szpunar, Joanna

doi:10.1002/mas.20069

Cited by 190 publications

(159 citation statements)

References 303 publications

(435 reference statements)

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“…Recently the focus has shifted towards mass spectrometric detection such as ESI-MS [25,26] and inductively coupled plasma (ICP)-MS [27][28][29][30], opening new possibilities for the characterization of metallodrug interactions with biological targets [7,31]. Especially ICP-MS, the unrivalled detector in terms of specificity and LOD of metals bound to biomolecules, seems best-suited for quantification of adducts, especially if only present in traces [32,33].…”

Section: Introductionmentioning

confidence: 99%

Capillary electrophoresis hyphenated to inductively coupled plasma‐mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasma

et al. 2008

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Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasmaThe development of metal-based chemotherapeutics lacks methods which are capable of providing early indication on the potential of new metal complexes as future anticancer drugs. Since most of these compounds are administered intravenously, serum proteins are the first available biological binding partners in the bloodstream. For platinum-based anticancer drugs the interaction with serum proteins is regarded as an important contribution to the side effects accompanying chemotherapy. In contrast, newly developed ruthenium compounds are thought to be transported into the tumor in a protein-bound form. In here, the application of CE hyphenated to inductively coupled plasma (ICP)-MS, applying Polybrene-coated capillaries, is demonstrated for studying the interaction of indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) with HSA and transferrin, which are important transport proteins. Furthermore, the applicability of the method to human serum and plasma and, more importantly, to real-world patient samples was proven. KP1019 was found to bind to a high degree to HSA both in serum, plasma and the patient samples. Only minor fractions of ruthenium were found attached to other proteins.

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Section: Introductionmentioning

confidence: 99%

Capillary electrophoresis hyphenated to inductively coupled plasma‐mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasma

et al. 2008

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“…These techniques allow for the simultaneous determination of several elements (ICP/ MS) or metal-chelate molecules (ESI/MS). ICP/MS is less selective than ESI/MS, but offers higher sensitivity and a larger dynamic range [14]. A problem when using ESI/MS in the analysis of environmental matrices is the poor tolerance to nonvolatile salts, which may reduce sensitivity.…”

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confidence: 99%

Determination of synthetic ferric chelates used as fertilizers by liquid chromatography-electrospray/mass spectrometry in agricultural matrices

Álvarez‐Fernández

Orera

Abadı́a

et al. 2007

J. Am. Soc. Mass Spectrom.

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A high-performance liquid chromatography-electrospray ionization/mass spectrometry (time of flight) method has been developed for the simultaneous determination of synthetic . The average intraday repeatability values were ϳ0.5 and 5% for retention time and peak area, respectively, whereas the interday repeatability values were ϳ0.7 and 8% for retention time and peak area, respectively. The method was validated using four different agricultural matrices, including nutrient solution, irrigation water, soil solution, and plant xylem exudates, spiked with Fe(III)-chelate standards and their stable isotope-labeled corresponding chelates. Analyte recoveries found were in the ranges 92-101% (nutrient solution), 89 -102% (irrigation water), 82-100% (soil solution), and 70 -111% (plant xylem exudates). Recoveries depended on the analyte, with Fe(III)-EDTA and Fe(III)-DTPA showing the lowest recoveries (average values of 87 and 88%, respectively, for all agricultural matrices used), whereas for other analytes recoveries were between 91 and 101%. The method was also used to determine the real concentrations of Fe(III)-chelates in commercial fertilizers. Furthermore, the method is also capable of resolving two more synthetic Fe(III)-chelates, Fe(III)-EDDHSA and Fe(III)-ED-DCHA, whose exact quantification is not currently possible because of lack of commercial standards. (J Am Soc Mass Spectrom 2007, 18, 37-47)

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“…Inductively coupled plasma mass spectrometry (ICPMS) provides a means to screen samples for the presence of organic-metal complexes. This approach has the major advantage that sensitivity is not dependent on the chemical species of the organic ligand and provides a quantitative measurement of each analyte [Lobiński et al, 2006]. However, it does not provide information on the species identity.…”

Section: Identifying Ligands In the Marine Environmentmentioning

confidence: 99%

“…Two complementary methods have been used to detect organic-metal complexes: inductively coupled plasma mass spectrometry (ICPMS) and electrospray ionization mass spectrometry (ESIMS) [Lobiński et al, 2006;Pedrero et al, 2012;Grevenstuk et al, 2013;Grillet et al, 2014]. In the case of ICPMS, as the metal complexes elute from the chromatography column, the metal is atomized and detected directly as the elemental ion.…”

Section: Introductionmentioning

confidence: 99%

Molecular determination of marine iron ligands by mass spectrometry

Boiteau¹

2016

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Abstract:Marine microbes produce a wide variety of metal binding organic ligands that regulate the solubility and availability of biologically important metals such as iron, copper, cobalt, and zinc.In marine environments where the availability of iron limits microbial growth and carbon fixation rates, the ability to access organically bound iron confers a competitive advantage. Thus, the compounds that microbes produced to acquire iron play an important role in biogeochemical carbon and metal cycling. However, the source, abundance, and identity of these compounds are poorly understood. To investigate these processes, sensitive methodologies were developed to gain a compound-specific window into marine iron speciation by combining trace metal clean sample collection and chromatography with inductively coupled plasma mass spectrometry (LC-ICPMS) and electrospray ionization mass spectrometry (LC-ESIMS). Coupled with isotope pattern assisted search algorithms, these tools provide a means to quantify and isolate specific iron binding ligands from seawater and marine cultures, identify them based on their mass and fragmentation spectra, and investigate their metal binding kinetics.Using these techniques, we investigated the distribution and diversity of marine iron binding ligands. In cultures, LC-ICPMS-ESIMS was used to identify new members of siderophore classes produced by marine cyanobacteria and heterotrophic bacteria, including synechobactins and marinobactins. Applications to natural seawater samples from the Pacific Ocean revealed a wide diversity of both known and novel metal compounds that are linked to specific nutrient regimes. Ferrioxamines B, E, and G were identified in productive coastal waters near California and Peru, in oligotrophic waters of the North and South Pacific Gyre, and in association with zooplankton grazers. Siderophore concentrations were up to five-fold higher in iron-deficient offshore waters (9pM) and were dominated by amphibactins, amphiphilic siderophores that partition into cell membranes. Furthermore, synechobactins were detected within nepheloid layers along the continental shelf. These siderophores reflect adaptations that impact dissolved iron bioavailability and thus have important consequences for marine ecosystem community structures and primary productivity. The ability to map and characterize these compounds has opened new opportunities to better understand mechanisms that link metals with the microbes that use them. 4Acknowledgements:

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Mass spectrometry in bioinorganic analytical chemistry

Cited by 190 publications

References 303 publications

Capillary electrophoresis hyphenated to inductively coupled plasma‐mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasma

Capillary electrophoresis hyphenated to inductively coupled plasma‐mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasma

Determination of synthetic ferric chelates used as fertilizers by liquid chromatography-electrospray/mass spectrometry in agricultural matrices

Molecular determination of marine iron ligands by mass spectrometry

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