Markers of subclinical atherosclerosis in schoolchildren with obesity and metabolic syndrome

Al-Shorman, Alaa; Al-Domi, Hayder; Faqih, Ahmad

doi:10.4414/smw.2020.14446

Cited by 7 publications

(9 citation statements)

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“…Concentration of IL-1b in our study did not show significant association, although in a study with severely obese school children, IL-1b, IL-6, and TNF-a levels were significantly higher in severely obese children with metabolic syndrome, compared to a normal body weight group (Al-Shorman et al, 2017), IL-1b is associated with low-intensity inflammation, although we did not observe this.…”

Section: Discussioncontrasting

confidence: 99%

Inflammatory Cytokine IFNγ, IL-6, and IL-10 Association with Childhood Obesity

Kupča

Jurka

Marksa

et al. 2021

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Childhood obesity carries a high risk of serious life-threatening cardiometabolic diseases in adulthood, which are associated with low-grade inflammation. The aim of the present study was to measure serum cytokine concentrations in obese children recruited during endocrinology consultations and compared to lean control the results. Blood serum concentrations of interferon gamma (IFNγ), IL-1β, Interleukin 6 IL-6, IL-10, and TNF-α were analysed applying Luminex xMap technology with Millipore reagent kits. Statistical analyses were performed using t-test comparisons and Spearman correlations. Obese children had highly significant increased levels of circulating IFNγ (p < 0.0001), IL-6 (p < 0.0001), and IL-10 (p < 0.0001), compared to lean controls. IL-1β and TNFα levels, however, were not elevated. Significant correlation of serum cytokines to per cent excess body mass was only observed with IL-6 (rs = 0.21, p < 0.03), although IL-1β (rs = 0.18, p < 0.08) results were suggestive of a trend. A significant association of obesity in childhood with serum concentrations of IFNγ, IL-6, and IL-10 is consistent with a role for low-grade inflammatory processes early in the aetiology of this disease. IL-6 further appears to be a candidate cytokine for assessment of degree of sub-acute inflammation associated with excess weight in the young.

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Section: Discussioncontrasting

confidence: 99%

Inflammatory Cytokine IFNγ, IL-6, and IL-10 Association with Childhood Obesity

Kupča

Jurka

Marksa

et al. 2021

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…NO is a marker of vascular injury. 23,24 Both CO and SO could significantly reduced the serum NO levels at weeks 4, 6, and 8 (Figure 4C). This result was consistent with the above results of serum CRP and TNF-α, indicating that CO can attenuate atherosclerosis by preventing the production of proinflammatory factors, such as CRP, TNF-α, and NO, in mice.…”

Section: Resultsmentioning

confidence: 93%

“…TNF-α is a pro-inflammatory cytokine produced by activated macrophages, and it can exacerbate inflammatory injury of atherosclerosis. , Both CO and SO could significantly reduce serum TNF-α levels at weeks 4, 6, and 8 compared to the control (Figure B).…”

Section: Resultsmentioning

confidence: 98%

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Cannabis Seed Oil Alleviates Experimental Atherosclerosis by Ameliorating Vascular Inflammation in Apolipoprotein-E-Deficient Mice

Huang

Zeng

Ling

et al. 2021

J. Agric. Food Chem.

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In recent decades, epidemiological, clinical, and experimental studies have demonstrated that a diet with antioxidant or anti-inflammatory function plays a central role in the prevention of atherosclerosis (AS). The purpose of this study was to explore the effects of Cannabis seed oil (CO) administration on in vitro antioxidant capacity as well as blood lipid profiles, lipid peroxidation, inflammatory response, and endothelial cell integrity. Female ApoE–/– mice were fed a high-cholesterol diet and administrated with CO or phosphate-buffered saline (PBS) and seal oil by gavage for 8 weeks. The results show that CO administration reduced the levels of serum triglycerides and low-density lipoprotein cholesterol at week 6. Additionally, a decrease in serum tumor necrosis factor α and nitric oxide was also observed. Moreover, results from CD31 staining and scanning electron microscopy revealed that CO treatment alleviated the endothelial cell damage and lipid deposition induced by a high-cholesterol diet. The ratio of lesion area to the total aorta area was 19.57% for the CO group, which was lower than the PBS control group (24.67%). Collectively, CO exerted anti-atherosclerotic effects by modulating serum lipid profiles and inflammatory responses and improving endothelial cell integrity and arterial lipid deposition. The results provide a promising preventive strategy for the early progression of AS.

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“…Adipose tissue restricts movement of the respiratory muscles and causes decreased oxygen saturation, which may already be compromised in COVID-19 disease [20]. It has also been observed that obese children and adolescents have higher blood pressure, which may cause endothelial dysfunction [21]. As endothelial damage is thought to be one of the underlying mechanisms of the SARS-CoV-2 virus, this may place obese children at an increased risk of severe infection [19].…”

Section: Bmimentioning

confidence: 99%

COVID-19 in Pediatric Inpatients: A Multi-Center Observational Study of Factors Associated with Negative Short-Term Outcomes

et al. 2021

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Most cases of COVID-19 in children and adolescents are mild or asymptomatic, but a small number of individuals may develop severe disease, requiring PICU admission and/or mechanical ventilation. We assessed the factors associated with negative short-term outcomes of COVID-19 in 82 pediatric patients at three hospitals within the United States during the spring and summer of 2020 using medical records, laboratory data, and imaging studies of all patients admitted with a positive RT-PCR test for SARS-CoV-2. We found that older patients were more likely to have an extended hospital stay, and those with high BMIs (over 25) were more likely to be admitted to the PICU during the early pandemic. In addition, older patients, those with high BMIs, and those with underlying medical conditions, were more likely to receive respiratory support. Given the association of age, BMI, and underlying medical conditions with more severe COVID-19, clinicians should keep these factors in mind when treating patients.

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Markers of subclinical atherosclerosis in schoolchildren with obesity and metabolic syndrome

Cited by 7 publications

References 0 publications

Inflammatory Cytokine IFNγ, IL-6, and IL-10 Association with Childhood Obesity

Inflammatory Cytokine IFNγ, IL-6, and IL-10 Association with Childhood Obesity

Cannabis Seed Oil Alleviates Experimental Atherosclerosis by Ameliorating Vascular Inflammation in Apolipoprotein-E-Deficient Mice

COVID-19 in Pediatric Inpatients: A Multi-Center Observational Study of Factors Associated with Negative Short-Term Outcomes

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