Markers of Inflammation and Fibrosis Are Related to Cardiovascular Damage in Hypertensive Patients with Metabolic Syndrome

Sciarretta, Sebastiano; Ferrucci, Andrea; Ciavarella, Giuseppino Massimo; Paolis, Paola De; Venturelli, Vanessa; Tocci, Giuliano; Biase, Luciano De; Rubattu, Speranza; Volpe, Massimo

doi:10.1016/j.amjhyper.2007.01.023

Cited by 94 publications

(70 citation statements)

References 31 publications

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“…In agreement with these studies, we found a significant association between lower levels of TGF-β1 and TGF-β2 and an increased risk of recurrent VTE. In contrast, other studies have shown an association between TGF-β and the development of metabolic syndrome and cardiovascular damage [24,25]. TGF-β was also weakly associated with factor VII in patients with hypercholesterolemia [26].…”

Section: Discussioncontrasting

confidence: 39%

Transforming growth factor (TGF)-β levels and unprovoked recurrent venous thromboembolism

Memon

Sundquist

Wang

et al. 2014

J Thromb Thrombolysis

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Section: Discussioncontrasting

confidence: 39%

Transforming growth factor (TGF)-β levels and unprovoked recurrent venous thromboembolism

Memon

Sundquist

Wang

et al. 2014

J Thromb Thrombolysis

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“…Although a wide range of serum TNF-a levels has been reported in different populations, our results suggests a TNF-a cut-point value that is consistent with the recently reported range of control subjects. TNF-a levels of normotensive subjects were significantly lower than levels found in hypertensive individuals with MS diagnosis (23). Moreover, TNF-a levels differed between hypertensive subjects with or without MS.…”

Section: Discussionmentioning

confidence: 60%

Establishment of a cut‐point value of serum TNF‐α levels in the metabolic syndrome

Gurrola-Díaz

Sánchez‐Enríquez

García-López

et al. 2009

Clinical Laboratory Analysis

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Cardiovascular diseases and type 2 diabetes are the major causes of mortality in Mexico. Metabolic syndrome (MS) is a cluster of factors that increase the risk to develop such diseases. Previous studies have shown that MS is associated with high tumor necrosis factor (TNF-a) levels. In fact, TNF-a has been proposed to be a useful marker for clinical diagnosis of inflammation at an early stage. Therefore, we analyzed TNF-a concentrations in Mexican individuals with or without MS and related these levels to the associated MS components. Clinical, anthropometric, and biochemical data were analyzed in 41 healthy and 39 MS individuals. Individuals were similarly grouped by age and gender.The serum TNF-a levels measured by a highly sensitive enzyme-linked immunosorbent assay (ELISA) kit were increased significantly in MS subjects compared with healthy individuals (Po0.001). The assay showed 78.1% sensitivity and 61.5% specificity with a cut-point level of 1.36 pg/mL. TNF-a levels higher than the cut-point value were correlated with insulin resistance indices. These findings support the hypothesis that serum TNF-a concentration could be a useful marker for early MS diagnosis. Nevertheless, we suggest the establishment of specific cut-point values in each studied population to evaluate potential clinical applications.

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“…MetS is known to be associated with deterioration in LV systolic and diastolic functions [3][4][5]. Myocardial fibrosis is thought to be one of the contributors to this deterioration [6,7,18]. Myocardial fibrosis can be diagnosed histopathologically and with the help of cardiac magnetic resonance imaging and scintigraphic methods [19,20].…”

Section: Discussionmentioning

confidence: 99%

“…MetS has been shown to be associated with left ventricular (LV) systolic and diastolic dysfunctions [3][4][5]. The mechanism behind cardiac impairment in MetS is multifactorial, but one of the pivotal contributors is thought to be myocardial fibrosis [6,7].…”

Section: Introductionmentioning

confidence: 99%

Fragmented QRS complexes are associated with left ventricular systolic and diastolic dysfunctions in patients with metabolic syndrome

Oner

Ertürk²,

Birant³

et al. 2015

Cardiol J.

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041). MetS was associated with subclinical LV systolic and LV diastolic dysfunctions. In subgroup analyses of MetS patients, the presence of fQRS on ECG had a higher E/E' ratio and lower E' velocity, indicating pronounced diastolic dysfunction, as well as lower isovolumic acceleration (IVA), indicating profound subclinical LV systolic dysfunction. E/E' ratio and IVA were independent predictors of fQRS presence in patients with MetS. Conclusions: Fragmented QRS is more common among MetS patients compared to non--MetS patients. The presence of fQRS is associated with pronounced subclinical LV systolic and diastolic dysfunctions in MetS patients. (Cardiol J 2015; 22, 6: 691-698)

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Markers of Inflammation and Fibrosis Are Related to Cardiovascular Damage in Hypertensive Patients with Metabolic Syndrome

Abstract: Cardiovascular damage is more frequent in hypertensives with MS than in hypertensives without MS, and this is significantly related to the increased levels of inflammation and fibrosis found in hypertensives with MS.

Cited by 94 publications

References 31 publications

Transforming growth factor (TGF)-β levels and unprovoked recurrent venous thromboembolism

Transforming growth factor (TGF)-β levels and unprovoked recurrent venous thromboembolism

Establishment of a cut‐point value of serum TNF‐α levels in the metabolic syndrome

Fragmented QRS complexes are associated with left ventricular systolic and diastolic dysfunctions in patients with metabolic syndrome

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