Markedly elevated serum levels of calcium-binding S100A8/A9 proteins in psoriatic arthritis are due to activated monocytes/macrophages

Aochi, Seiko; Tsuji, Kazuhide; Sakaguchi, Masakiyo; Huh, Nam-ho; Tsuda, Tatsuya; Yamanishi, Kiyofumi; Komine, Mayumi; Iwatsuki, Keiji

doi:10.1016/j.jaad.2010.02.049

Cited by 50 publications

(38 citation statements)

References 23 publications

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“…2b), and correlated with disease severity (Fig. S5) compatible with a previous study (14). However, serum S100A8 had no differences between HCs and AD patients (Fig.…”

Section: Resultssupporting

confidence: 90%

DAMP molecules S100A9 and S100A8 activated by IL‐17A and house‐dust mites are increased in atopic dermatitis

Jin

Park

Shin

et al. 2014

Experimental Dermatology

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Further research is needed to determine the functional role of lymphatic vascular electrotaxis in vivo and to investigate possible applications, including stem cell maintenance (9). ConclusionsDirect-current electrical stimulation promoted both cytoskeleton extension of LECs via the FAK pathway and calcium influx, leading to induction of proliferation and migration of LECs to the cathode in vitro. Electric stimuli could be used to control lymphatic function and its related diseases. AcknowledgementsWe would like to thank Suin Kyo for her technical assistance. K.K and Y.M designed, performed the research study and analysed the data. M.S, K.F, N.S and Y.M performed the research and analysed the data. K.K wrote the paper, Y.T and T.A contributed the development of DC application instrument for the study. Conflict of interestsThe authors have declared no conflicting interests. Supporting InformationAdditional supporting data may be found in the supplementary information of this article. Data S1. Complete materials and methods. Figure S1. Schematic illustration of DC application for migration assay of LECs. Abstract: S100A9 and S100A8 are called damage-associated molecular pattern (DAMP) molecules because of their proinflammatory properties. Few studies have evaluated S100A9 and S100A8 function as DAMP molecules in atopic dermatitis (AD). We investigated how house-dust mites affect S100A9 and S100A8 expression in Th2 cytokine-and Th17 cytokine-treated keratinocytes, and how secretion of these molecules affects keratinocyte-derived cytokines. Finally, we evaluated expression of these DAMP molecules in AD patients. S100A9 expression and S100A8 expression were strongly induced in IL-17A-and Dermatophagoides (D.) farinae-treated keratinocytes, respectively. Furthermore, co-treatment with D. farinae and IL-17A strongly increased expression of S100A9 and S100A8 compared with D. farinae-Th2 cytokine co-treatment. The IL-33 mRNA level increased in a dose-dependent manner in S100A9-treated keratinocytes, but TSLP expression did not change. S100A8/A9 levels were also higher in the lesional skin and serum of AD patients, and correlated with disease severity. Taken together, S100A9 and S100A8 may be involved in inducing DAMPmediated inflammation in AD triggered by IL-17A and house-dust mites.

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“…2b), and correlated with disease severity (Fig. S5) compatible with a previous study (14). However, serum S100A8 had no differences between HCs and AD patients (Fig.…”

Section: Resultssupporting

confidence: 90%

DAMP molecules S100A9 and S100A8 activated by IL‐17A and house‐dust mites are increased in atopic dermatitis

Jin

Park

Shin

et al. 2014

Experimental Dermatology

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“…The activation of the monocyte/macrophage system might be responsible for the increase in CLP in patients with arthritis compared with psoriasis. 54,100 As in other SpA, in PSA, CLP is typically localized in perivascular areas in the synovial tissue. 54 Such distribution might be related to the distinctive synovial macro-vascular changes found in PSA, which are not observed in RA.…”

Section: Psoriatic Arthritismentioning

confidence: 98%

“…54 Such distribution might be related to the distinctive synovial macro-vascular changes found in PSA, which are not observed in RA. 101 CLP seems to be a useful biomarker since it correlates with clinical measures, including the number of involved joints, 100 the Ritchie Articular Index, and systemic inflammatory indices. 54 In a study by Kane et al 54 in PSA patients, CLP was a sensitive and specific indicator of treatment response, as previously reported in SpA.…”

Section: Psoriatic Arthritismentioning

confidence: 99%

Calprotectin in rheumatic diseases

Ometto

Friso

Astorri

et al. 2016

Exp Biol Med (Maywood)

132

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Calprotectin is an acute-phase protein produced by monocytes and neutrophils in the circulation and inflamed tissues. Calprotectin seems to be more sensitive than CRP, being able to detect minimal residual inflammation and is a candidate biomarker in inflammatory diseases. High serum levels are associated with some severe manifestations of rheumatic diseases, such as glomerulonephritis and lung fibrosis. Calprotectin levels in other fluids, such as saliva and synovial fluid, might be helpful in the diagnosis of rheumatic diseases. Of interest is also the potential role of calprotectin as a target of treatment. AbstractCalprotectin is a heterodimer formed by two proteins, S100A8 and S100A9, which are mainly produced by activated monocytes and neutrophils in the circulation and in inflamed tissues. The implication of calprotectin in the inflammatory process has already been demonstrated, but its role in the pathogenesis, diagnosis, and monitoring of rheumatic diseases has gained great attention in recent years. Calprotectin, being stable at room temperature, is a candidate biomarker for the follow-up of disease activity in many autoimmune disorders, where it can predict response to treatment or disease relapse. There is evidence that a number of immunomodulators, including TNF-a inhibitors, may reduce calprotectin expression. S100A8 and S100A9 have a potential role as a target of treatment in murine models of autoimmune disorders, since the direct or indirect blockade of these proteins results in amelioration of the disease process. In this review, we will go over the biologic functions of calprotectin which might be involved in the etiology of rheumatic disorders. We will also report evidence of its potential use as a disease biomarker.

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“…However, only a few studies have addressed elevated calprotectin levels in the skin or serum in AD. 12,21 Orivuori et al 22 demonstrated that infants with high fecal calprotectin levels at the age of 2 months had an increased risk of developing AD by age 6. They concluded that imbalance of the gut microbiota and intestinal inflammation in early life was associated with later development of AD.…”

Section: Discussionmentioning

confidence: 99%

Elevated fecal calprotectin levels are associated with severity of atopic dermatitis in children

Seo

Ahn

et al. 2017

Asian Pac J Allergy Immunol

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Markedly elevated serum levels of calcium-binding S100A8/A9 proteins in psoriatic arthritis are due to activated monocytes/macrophages

Abstract: Although serum levels of S100A8/A9 were increased in all types of psoriasis examined, patients with PA had higher levels of S100A8/A9, probably because of an activated monocyte/macrophage system.

Cited by 50 publications

References 23 publications

DAMP molecules S100A9 and S100A8 activated by IL‐17A and house‐dust mites are increased in atopic dermatitis

DAMP molecules S100A9 and S100A8 activated by IL‐17A and house‐dust mites are increased in atopic dermatitis

Calprotectin in rheumatic diseases

Elevated fecal calprotectin levels are associated with severity of atopic dermatitis in children

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