Markedly elevated cytokines in pleural effusion during the ovarian hyperstimulation syndrome: transudate or ascites?

Mola, J. Ricardo Loret de; Arredondo-Soberon, Francisco; Randle, Christopher P.; Tureck, Richard T.; Friedlander, Miriam A.

doi:10.1016/s0015-0282(97)81383-0

Cited by 27 publications

(33 citation statements)

References 5 publications

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“…It would be rather unlikely that a systemic peptide will target its vascular permeability effects on the pleural space unilaterally, without affecting any other serosal membrane. Furthermore, pleural fluid IL-6 levels are comparable to values reported in ascites, which are 100 times higher than normal serum, also supporting a passive movement from the abdomen into the pleural space (Loret de Mola et al, 1997). The normal drainage of the diaphragmatic lymphatics would explain the nature of pleural effusions in cases of chronic ascites such as cirrhosis, whereas anatomical defects provide a more adequate explanation to the acute hydrothorax associated with peritoneal dialysis and OHSS.…”

Section: Pathophysiology Of Unilateral Pleural Effusions In the Ovarisupporting

confidence: 58%

“…The pathophysiology of massive hydrothorax concurrently with minimal ascites has been described previously (Loret de Mola et al, 1997). It has been proposed that the diaphragmatic lymphatics are a route for the transfer of ascites into the pleural space in cases of cirrhosis and Meigs syndrome.…”

Section: Pathophysiology Of Unilateral Pleural Effusions In the Ovarimentioning

confidence: 98%

“…This syndrome could be precipitated by an ovarian product, vasoactive peptide or cytokine that has been released into the peritoneal cavity by the ovary, or that has gained access to the systemic circulation directly from the corpus luteum and/or serosal vessels (Loret de Mola et al, 1996). Specifically, interleukin-6 (IL-6) has been shown to be markedly elevated in the follicular fluid and ascites, as well as serum and pleural effusions from patients with severe OHSS (Loret de Mola et al, 1996, 1997.…”

Section: Pathophysiology Of Unilateral Pleural Effusions In the Ovarimentioning

confidence: 99%

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Pathophysiology of unilateral pleural effusions in the ovarian hyperstimulation syndrome

Mola

1999

Human Reproduction

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Section: Pathophysiology Of Unilateral Pleural Effusions In the Ovarisupporting

confidence: 58%

Section: Pathophysiology Of Unilateral Pleural Effusions In the Ovarimentioning

confidence: 98%

Section: Pathophysiology Of Unilateral Pleural Effusions In the Ovarimentioning

confidence: 99%

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Pathophysiology of unilateral pleural effusions in the ovarian hyperstimulation syndrome

Mola

1999

Human Reproduction

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“…Intensive positive immunohistochemical reaction to antibody anti-β-HCG (c and d) (×10; ×100) [17]. Prostaglandins and cytokines may play a role in the pathophysiology of ARDS, as they are also incriminated in the pathophysiology of OHSS [18]. The hallmark of OHSS is an increase in capillary permeability resulting in a fluid shift from the intravascular space to third space compartments [19].…”

Section: Discussionmentioning

confidence: 99%

“…Interleukin-6 is markedly elevated in the peritoneal fluid and serum of patients with severe OHSS [18]. This syndrome may be precipitated by an ovarian product or cytokine secreted directly into the peritoneal cavity by the ruptured follicle and early corpus luteum.…”

Section: Discussionmentioning

confidence: 99%

An immunohistochemical study in a fatality due to ovarian hyperstimulation syndrome

et al. 2006

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Ovarian hyperstimulation syndrome (OHSS) is a complication occurring in the luteal phase of a menstrual cycle in which ovulation induction or ovarian hyperstimulation for assisted reproduction techniques has been performed. Our report concerns the death of a 31-year-old woman with primary infertility on recombinant follicle stimulating hormone therapy (Gonal-F) who developed a fatal adult respiratory distress syndrome. Immunohistochemical investigation of lung and uterine samples was performed utilizing monoclonal antibodies for antisurfactant apoprotein (PE-10) and polyclonal antibodies anti-IL-6, IL-8, IL-10, TNFalpha for lungs, and polyclonal antibodies anti-beta-HCG (human chorionic gonadotropin) for uterus. The knowledge of macroscopic and histologic findings should be of special interest for all those who perform autopsies in these victims. The exact pathogenesis of OHSS remains a mystery; so for the diagnosis of suspected OHSS, the forensic pathologist must use all the modern laboratory armament to validate the diagnosis in the extremely rare fatal cases due to this syndrome.

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Translational Research in Pleural Infection and Beyond

Lee

Idell

Stathopoulos

2016

Chest

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The incidence of pleural infection has been rising in recent years. Intrapleural therapy with tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) has significantly reduced the need for surgery, and its impact on clinical care is rising worldwide. Efforts are underway to optimize the delivery regimen and establish the short and longer term effects of this therapy. The complex interactions of bacterial infection within the pleura with inflammatory responses and clinical interventions (antibiotics and tPA/DNase or other fibrinolysins) require further studies to improve future treatment options. Intrapleural instillation of tPA potently induces pleural fluid formation, principally via a monocyte chemotactic protein (MCP)-1 dependent mechanism. Activation of transcriptional programs in pleural resident cells and infiltrating cells during pleural infection and malignancy results in the local secretion of a cocktail of proinflammatory signaling molecules (including MCP-1) within the pleural confines that contributes to effusion formation. Understanding the biology of these molecules and their interaction may provide novel targets for pleural fluid control.

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Markedly elevated cytokines in pleural effusion during the ovarian hyperstimulation syndrome: transudate or ascites?

Cited by 27 publications

References 5 publications

Pathophysiology of unilateral pleural effusions in the ovarian hyperstimulation syndrome

Pathophysiology of unilateral pleural effusions in the ovarian hyperstimulation syndrome

An immunohistochemical study in a fatality due to ovarian hyperstimulation syndrome

Translational Research in Pleural Infection and Beyond

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