Marked increase in breast cancer incidence in young women: A 10-year study from Northern Iran, 2004–2013

Abstract

Introduction: Breast cancer is the most frequent cancer among women worldwide. Breast cancer incidence in young women is a health issue of concern, especially in middle-income countries such as Iran. The aim of this study is to report the breast cancer incidence variations in Golestan province, Iran, over a 10-year period (2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013). Methods: We analyzed data from the Golestan Population-based Cancer Registry (GPCR), which is a high-quality cancer registry collecting data on primary cancers based on standard protocols throughout the Golestan province. Age-standardized incidence rates (ASRs) and age-specific incidence rates per 100,000 person-years were calculated. Time trends in ASRs and age-specific rates were evaluated using Joinpoint regressions. The average annual percentage change (AAPC) with correspondence 95% confidence intervals (95%CIs) were calculated. Results: A total of 2106 new breast cancer cases were diagnosed during the study period. Most cases occurred in women living in urban areas: 1449 cases (68%) versus 657 cases (31%) in rural areas. Statistically significant increasing trends were observed over the 10-year study period amongst women of all ages (AAPC = 4.4; 95%CI: 1.2-7.8) as well as amongst women in the age groups 20-29 years (AAPC = 10.0; 95%CI: 1.7-19.0) and 30-39 years (AAPC = 5.1; 95%CI: 1.4-9.0). Conclusion:The incidence of breast cancer increased between 2004 and 2013 in Golestan province amongst all age groups, and in particular amongst women aged 20-39 years. Breast cancer should be considered a high priority for health policy making in our community.The incident rate of breast cancer is 46.3 per 100,000 worldwide [2], and the total number of breast cancer cases is predicted to increase in the future, reaching 3 million in 2030 [2,3].Incidence rates are higher in high-income countries: North America, Western Europe and Oceania, as compared with Africa, South America and Asia [2]. The breast cancer screening program, as well as a higher prevalence of risk factors, explain the higher incidence in these

The role of long non‑coding RNA H19 in breast cancer (Review)

“…Breast cancer is the most common malignant tumor in women in the majority of countries and usually occurs in women at 35–70 years of age (69,70). In recent years, breast cancer incidence has demonstrated a younger trend (71). The incidence of breast cancer had been demonstrated to be associated with multiple factors, such as a family history of breast cancer, early menarche, not being married, not having had children, radiographic exposure, long-term use of exogenous estrogen, postmenopausal obesity and alcohol consumption (72).…”

Qualitative Study of Health Information -Seeking Barriers among Mastectomy Patients

“…Breast cancer is one of the most common cancers among Iranian women, and also the statistics of Iran cancer registry center shows an increasing trend in breast cancer incidence over the recent years (Fazel et al, 2019). The mastectomy is a way to treat breast cancer by removing the breast with or without the lymph nodes.…”

Young Women With Breast Cancer in Brazil: A Population‐Based Study Epidemiology of Breast Cancer in Young Women

“…The Age standardized rate (ASR) in our study ranged from 3.0 to 5.3, which is less than the data released by GLOBALCAN, where the ASR in the World was 8.3% and in Brazil 10.8%. Therefore, the incidence in Rio Grande do Norte was stable, unlike the situation in other cities in Brazil, such as Porto Alegre and Goiânia, which had a variation in the incidence rate from one year to the next of 4.6 and 4.4%, respectively [18].…”

“…1A). 18.9% in stage IV, 12.2% stage I and 3.9% in situ carcinoma. More than half of the tumors were positive for hormone receptors, where 51.6% were positive for the progesterone receptor (PR) and 59.1% for the estrogen receptor (ER).…”

“…Younger women have more aggressive disease, including higher stages, negative hormone receptors, increased basal-like subtypes, lymph node positivity, and larger tumors. The factors of pre-and postmenopausal women differ because, in that same study, it was shown that the higher waist to hip ratio was associated with a reduced risk of breast cancer among young women, but with a high risk among older women [18,24,36].…”