2004
DOI: 10.1074/jbc.m304528200 View full text |Buy / Rent full text
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Abstract: The MARK protein kinases were originally identified by their ability to phosphorylate a serine motif in the microtubule-binding domain of tau that is critical for microtubule binding. Here, we report the cloning and expression of a novel human paralog, MARK4, which shares 75% overall homology with MARK1-3 and is predominantly expressed in brain. Homology is most pronounced in the catalytic domain (90%), and MARK4 readily phosphorylates tau and the related microtubuleassociated protein 2 (MAP2) and MAP4. In con… Show more

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