Biochemical Pharmacology volume 80, issue 10, P1497-1506 2010 DOI: 10.1016/j.bcp.2010.08.001 View full text
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Ioana Abraham, Sandeep Jain, Chung-Pu Wu, Mohammad A. Khanfar, Yehong Kuang, Chun-Ling Dai, Zhi Shi, Xiang Chen, Liwu Fu, Suresh V. Ambudkar, Khalid El Sayed, Zhe-Sheng Chen

Abstract: Previously, we reported sipholenol A, a sipholane triterpenoid from the Red Sea sponge Callyspongia siphonella, as a potent reversal of multidrug resistance (MDR) in cancer cells that overexpressed P-glycoprotein (P-gp). Through extensive screening of several related sipholane triterpenoids that have been isolated from the same sponge, we identified sipholenone E, sipholenol L and siphonellinol D as potent reversals of MDR in cancer cells. These compounds enhanced the cytotoxicity of several P-gp substrate an…

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