Ioana Abraham, Sandeep Jain, Chung-Pu Wu, Mohammad A. Khanfar, Yehong Kuang, Chun-Ling Dai, Zhi Shi, Xiang Chen, Liwu Fu, Suresh V. Ambudkar, Khalid El Sayed, Zhe-Sheng Chen
Previously, we reported sipholenol A, a sipholane triterpenoid from the Red Sea sponge Callyspongia siphonella, as a potent reversal of multidrug resistance (MDR) in cancer cells that overexpressed P-glycoprotein (P-gp). Through extensive screening of several related sipholane triterpenoids that have been isolated from the same sponge, we identified sipholenone E, sipholenol L and siphonellinol D as potent reversals of MDR in cancer cells. These compounds enhanced the cytotoxicity of several P-gp substrate an…
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