2019
DOI: 10.1016/j.cell.2019.03.040
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Abstract: Microbes drive most ecosystems and are modulated by viruses that impact their lifespan, gene flow and metabolic outputs. However, ecosystem-level impacts of viral community diversity remains difficult to assess due to classification issues and few reference genomes. Here we establish a ~12-fold expanded global ocean DNA virome dataset of 195,728 60 viral populations, now including the Arctic Ocean, and validate that these populations form discrete genotypic clusters. Meta-community analyses revealed five ecolo… Show more

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Cited by 554 publications
(687 citation statements)
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References 116 publications
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“…Over the last years, metagenomics have provided a wealth of information that have been extremely useful to build more accurate ecological models (Brum and Sullivan, 2015). In marine ecosystems, in part thanks to sampling efforts with geographical coverage, such as Tara or Malaspina, the biogeography and diversity of viruses are starting to be explored (Mizuno et al, 2013;Paez-Espino et al, 2016;Roux et al, 2016;Lara et al, 2017;Gregory et al, 2019).…”
Section: Resultsmentioning
confidence: 99%
“…Over the last years, metagenomics have provided a wealth of information that have been extremely useful to build more accurate ecological models (Brum and Sullivan, 2015). In marine ecosystems, in part thanks to sampling efforts with geographical coverage, such as Tara or Malaspina, the biogeography and diversity of viruses are starting to be explored (Mizuno et al, 2013;Paez-Espino et al, 2016;Roux et al, 2016;Lara et al, 2017;Gregory et al, 2019).…”
Section: Resultsmentioning
confidence: 99%
“…As an example, although dozens of novel eukaryotic viruses have been identified in the mammalian enteric tract by metagenomic sequencing, culture systems for only a very limited number have been described to date [14,15]. Likewise, for phages, genomic sequences of thousands of novel phages can be identified in a single study [16,17], but very few have been isolated [18]. Thus, while (in the past) discovery of novel viruses was rate limiting, today the rate-limiting step has shifted to development of culture systems for the viruses that have been molecularly identified.…”
Section: Lack Of Culture Systems To Propagate Components Of the Viromementioning
confidence: 99%
“…As we already mentioned, our results identified Alteromonas, Erythrobacter, Marinobacter and Halomonas as the most abundant cultured OTUs and widely distributed genera in our dataset. We classified the first two as cosmopolitan taxa and the last two as regional taxa, based on the classification proposed in the study of Gregory et al [59]. These genera have been detected in other culture-dependent and cultureindependent studies from a wide variety of marine environments, including coastal, shelf, and open ocean waters [9,13,16,69,[73][74][75] corroborating their ubiquity.…”
Section: Extent Of Cosmopolitan and Locally Cultured Bacteriamentioning
confidence: 68%
“…4b) and covered almost all the oceanographic regions (Table S14). These were, thus, regionally distributed [59].…”
Section: Cosmopolitan Vs Locally Distribution Of Heterotrophic Bactermentioning
confidence: 99%
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