Marine‐derived Potential Anti‐inflammatory Agents

Kumar, Maushmi S.; Patravale, Vandana

doi:10.1002/9781119143802.ch116

Cited by 1 publication

(1 citation statement)

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“…This supremacy also comes with their various biological activities and chemical diversity. Herein, cytotoxicity or its related anti-cancer properties is the leading interest for these biological activities (Hanif et al 2019 ), followed by antibacterial and other distinct properties, ranging from antiviral properties that serve as potential leads for COVID-19 therapy (Geahchan et al 2021 ), enzyme inhibitors for pharmacological application (Ruocco et al 2017 ; Yamazaki et al 2020 ) to lead compounds for type II diabetes treatment (Abdjul et al 2017 ), including potential anti-inflammatory agents involved in various diseases such as heart disease, lung disease, bone health, depression, cancer, and anger and aggressive disorders (Kumar and Patravale 2020 ). Thus, the Indonesian marine sponges are an excellent source of bioactive compounds, especially with cytotoxic activity.…”

Section: Introductionmentioning

confidence: 99%

Structure–Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges

Panggabean

Adiguna

Murniasih³

et al. 2022

Rev. Bras. Farmacogn.

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Graphical abstract Indonesian marine natural products have been one of the most promising sources in the race to obtain potential drugs for cancer treatment. One of the primary producers of cytotoxic compounds is sponges. However, there are still limited sources of comprehensive reviews related to the relationship between the structure of isolated compounds and their cytotoxic activity. This review remarks the attempt to provide a preliminary guidance from the perspective of structure–activity relationship and its participation on marine natural products research. This guidance is segregated by the compound’s classes and their cytotoxic targets to obtain and organized a reliable summary of inter-study of the isolated compounds and their cytotoxicity. Structure–activity relationship is well-known for its ability to tune the bioactivity of a specific compound, especially on synthetic organic chemistry and in silico study but rarely used on natural product chemistry. The present review is intended to narrow down the endless possibilities of cytotoxicity by giving a predictable structure–activity relationship for active compounds. In addition, bioactive framework leads were selected by uncovering a noticeable structure–activity relationship with the intervention of cytotoxic agents from natural sources, especially Indonesian marine sponge.

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