Marihuana and Setting

Action of delta‐9‐tetrahydrocannabinol An approach to the active metabolite hypothesis

“…Although we found a considerable variation in responses be-tween individuals, the effect of the setting in which the drug was given was relatively negligible, at least with doses of marihuana having appreciable pharmacologic effects. 5 The present study suggests that these variations in response cannot be accounted for on the basis of differences in the rate of drug metabolism. Another alternative explanation for the variability of response is the difference in expectations (what psychologists call "set") about the drug effect among various subjects.…”

Strategies for Research on the Interactions of Drugs of Abuse: NIDA Research Monograph 68

“…The axiom is seldom tested. A study of marijuana and placebo cigarettes smoked under "favorable" and "unfavorable" conditions found no appreciable contribution of the extreme settings in which the drug was taken (Hollister et al 1975). Quite possibly, the psychological expectations or "set" of subjects are the major determinant of interindividual differences.…”

Correlations between Cannabis-induced Psychopathology and EEG before and after Drug Ingestion

“…somatic disposition (Broadhurst, 1975), previous experiences (Rushton et al, 1968) and personality factors (Eysenck, 1966, Claridge andBirchall, 1973); the importance of the experimental setting, i.e. the general condition during the experiment {Naditch et al, 1975), recently was questioned (Hollister et al, 1975).…”