Marching cohort of<i>Helicobacter pylori</i>infection over two decades (1988–2007): combined effects of secular trend and population migration

Deyi, Véronique Yvette Miendje; Vanderpas, Jean; Bontems, Patrick; Borre, C Van den; Koster, E. De; Cadranel, Samy; Burette, A

doi:10.1017/s095026881000110x

Cited by 32 publications

(25 citation statements)

References 26 publications

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“…The latter may contribute, as our data suggest continuing acquisition of H. pylori at least until the age of 7, consistent in children of Dutch and non-Dutch ethnicities. The higher H. pylori prevalence in children of non-Dutch ethnicity confirms findings of other studies [27, 28]. When comparing previous studies, the exact colonization rate of particular ethnic groups may differ due to differences in age or selected populations, but nevertheless it is clear that subjects of non-Western ethnicity comprise risk groups for H. pylori colonization within multi-ethnic populations of Western cities.…”

Section: Discussionsupporting

confidence: 85%

Intergenerational reduction inHelicobacter pyloriprevalence is similar between different ethnic groups living in a Western city

Hollander

Holster²,

Gilst³

et al. 2014

Gut

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Objective Helicobacter pylori (H. pylori) colonization rates in childhood have declined in Western populations, but it is unknown whether this trend is similar in children of non-Western ethnic backgrounds, born in a Western country. We aimed to identify H. pylori status in children, and determine both mother-to-child transmission and risk factors for colonization. Design Antibodies against H. pylori and cytotoxin-associated gene A (CagA) were measured in children participating in a population-based prospective cohort study in Rotterdam, the Netherlands. Information on demographics and characteristics was collected using questionnaires. Results We analysed the serum of 4,467 children (mean age 6.2 years ±0.5 SD) and compared the results with the H. pylori status of their mothers (available for 3,185 children). Overall, 438 (10%) children were H. pylori-positive, of whom 142 (32%) were CagA-positive. Independent risk factors for colonization were: maternal H. pylori positivity (OR 2.12; 95%CI 1.62–2.77), non-Dutch ethnicity (OR 2.05; 95%CI 1.54–2.73), female gender (OR 1.47; 95%CI 1.20–1.80), and lower maternal education level (OR 1.38; 95%CI 1.06–1.79). Comparing mothers and children, we found an intergenerational decrease of 76% and 77% for Hp+CagA− and Hp+CagA+-strains, respectively, consistent across all nine ethnic groups studied. Male gender, higher maternal educational level, and no older siblings, were independently associated with loss of H. pylori. Conclusions Although the highest H. pylori and CagA prevalence was found in children of non-Dutch ethnicities, the decreased colonization rates were uniform across all ethnic groups, implying the importance of environmental factors in H. pylori transmission in modern cities, independent of ethnicity.

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Section: Discussionsupporting

confidence: 85%

Intergenerational reduction inHelicobacter pyloriprevalence is similar between different ethnic groups living in a Western city

Hollander

Holster²,

Gilst³

et al. 2014

Gut

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“…The observed H. pylori colonization rate in the Dutch study subjects was consistent with a previous study in subjects of the same age . Studies evaluating H. pylori colonization in immigrant groups all showed higher infection prevalence than in native populations . A previous study of 288 adults in Rotterdam showed nearly similar positivity rates among different immigrant groups, however, higher prevalence in subjects of Dutch origin (46%) than we observed .…”

Section: Discussioncontrasting

confidence: 57%

Ethnicity is a strong predictor for Helicobacter pylori infection in young women in a multi‐ethnic European city

Hollander

Holster

Hoed

et al. 2013

J of Gastro and Hepatol

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BACKGROUND AND AIM At the same time that H. pylori prevalence is declining in Western countries, immigrants from developing countries with high H. pylori prevalence have settled in Western urban areas. Actual epidemiologic data on H. pylori in a migrant community may help in realizing a more selective approach to assess H. pylori-related diseases. We aimed to define H. pylori prevalence as well as risk groups for H. pylori in a cohort of young women living in a multi-ethnic European city. METHODS We measured IgG anti-H. pylori and CagA-antibodies in serum of pregnant women included in a population-based prospective cohort study. Information on demographics, and socio-economic status was collected by questionnaires. Chi-square and logistic regression were used. RESULTS In total, 3146 (46%) of the 6837 tested women (mean age 29.7 ± 5.3) were H. pylori-positive and 1110 (35%) of them were CagA-positive. The H. pylori prevalence in Dutch women was 24%, which was significantly lower than in non-Dutch women (64%; p<0.001). In particular, H. pylori positivity was found in 92% of Moroccan (OR 19.2; 95% CI 11.8-32.0), 80% of Cape Verdean (7.6; 5.0-11.5), 81% of Turkish (9.0; 6.7-12.1), 60% of Dutch Antillean (3.3; 2.3-4.7), and 58% of Surinamese women (3.0; 2.3-3.8). Among H. pylori-positive Dutch subjects, 19% were CagA-positive compared with 40% of the non-Dutch subjects (p<0.001). CONCLUSIONS Despite a general trend of declining prevalence in Western countries, H. pylori remains highly prevalent in migrant communities, which may constitute target groups for screening and eradication to prevent H. pylori-related diseases.

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“…Treatment with macrolides induces point mutations in the 23S rRNA gene that could result in the acquisition of resistance (41). Despite the heterogeneity of our population (33), mutations involved in CLR r were comparable to mutations reported previously by other studies in Europe, which were mainly A2142G/43G mutations and various combinations of the wild type as well as point mutations related to the presence of multiple isolates (mixed population) in the same biopsy specimen (1,12,31,37,43,44,49). In contrast with data from many previous studies (1,2,11,24), our study identified the A2142C mutation in some strains from children, probably due to the large number of isolates in our study.…”

Section: Vol 49 2011 Two-decade Survey Of H Pylori Resistance In Bmentioning

confidence: 94%

“…Samples from children were collected at the Queen Fabiola Children's University Hospital and at the Saint-Pierre University Hospital, while samples from adults were collected at the CHIREC/site de la Basilique, at the Brugmann University Hospital, and at the Saint-Pierre University Hospital, as previously described (33). Other invasive tests for H. pylori detection were also performed during upper GI endoscopy (histology and rapid urease tests).…”

Section: Methodsmentioning

confidence: 99%

Multicenter Survey of Routine Determinations of Resistance of Helicobacter pylori to Antimicrobials over the Last 20 Years (1990 to 2009) in Belgium

et al. 2011

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We analyzed the rates of antimicrobial resistance of Helicobacter pylori strains isolated from patients from 1990 to 2009 and identified risk factors associated with resistance. Gastric biopsy specimens were collected from several digestive disease centers in Brussels, Belgium. We routinely performed antimicrobial susceptibility testing for clarithromycin (CLR), metronidazole, amoxicillin, tetracycline, and ciprofloxacin. Evaluable susceptibility testing was obtained for 9,430 strains isolated from patients who were not previously treated for Helicobacter pylori infection (1,527 isolates from children and 7,903 from adults) and 1,371 strains from patients who were previously treated (162 isolates from children and 1,209 from adults). No resistance to amoxicillin was observed, and tetracycline resistance was very rare (<0.01%). Primary metronidazole resistance remained stable over the years, with significantly lower rates for isolates from children (23.4%) than for isolates from adults (30.6%). Ciprofloxacin resistance remained rare in children, while it increased significantly over the last years in adults. Primary clarithromycin resistance increased significantly, reaching peaks in 2000 for children (16.9%) and in 2003 for adults (23.7%). A subsequent decrease of resistance rates down to 10% in both groups corresponded to a parallel decrease in macrolide consumption during the same period. Multivariate logistic regression revealed that female gender, age of the patient of 40 to 64 years, ethnic background, the number of previously unsuccessful eradication attempts, and the different time periods studied were independent risk factors of resistance to clarithromycin, metronidazole, and ciprofloxacin. Our study highlights the need to update local epidemiological data. Thus, the empirical CLR-based triple therapy proposed by the Maastricht III consensus report remains currently applicable to our population.

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Marching cohort ofHelicobacter pyloriinfection over two decades (1988–2007): combined effects of secular trend and population migration

Cited by 32 publications

References 26 publications

Intergenerational reduction inHelicobacter pyloriprevalence is similar between different ethnic groups living in a Western city

Intergenerational reduction inHelicobacter pyloriprevalence is similar between different ethnic groups living in a Western city

Ethnicity is a strong predictor for Helicobacter pylori infection in young women in a multi‐ethnic European city

Multicenter Survey of Routine Determinations of Resistance of Helicobacter pylori to Antimicrobials over the Last 20 Years (1990 to 2009) in Belgium

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