Marcadores prognósticos de evolução neonatal de recém-nascidos de termo portadores de asfixia perinatal

Vargas, Nadia Sandra Orozco

doi:10.11606/d.5.2012.tde-29082012-135124

Cited by 1 publication

(2 citation statements)

References 7 publications

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“…According to the World Health Organization, 2.6 million newborns die in the first 28 days of life every year -and 75% of these deaths could be avoided. In Brazil, since the 1990s, neonatal death has been the main component of infant mortality 1,2 . The leading causes of neonatal death are congenital malformation, maternal factors, low birth weight, perinatal infections, prematurity, and respiratory injury, ranging from neonatal hypoxia to perinatal asphyxia (PA) 3,4 .…”

Section: Introductionmentioning

confidence: 99%

“…Among the respiratory problems, PA is responsible for 23% of neonatal deaths 3 , which can be diagnosed based on blood gas analysis and Apgar score. In the fifth minute of the newborn's life, the Apgar score becomes an essential tool for neuronal assessment 1 -considering that asphyxia during childbirth can produce long-term deficits in brain development 5 .…”

Section: Introductionmentioning

confidence: 99%

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Role of the NF-kB/parkin/vegfr-1 pathway associated with hypoxic-ischemic insult in germinal matrix samples of newborn infants

Ghirelli

Silva

Oricil

et al. 2023

Rev. paul. pediatr.

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Objective: Given the high proliferative activity of germinal matrix and its direct correlation with hypoxemia, it is necessary to investigate the possible molecular regulation pathways, to understand the existing clinical relationship between the hypoxic-ischemic insult and the biomarkers NF-kB, AKT-3, Parkin, TRK-C and VEGFR-1. Methods: A hundred and eighteen germinal matrix samples of the central nervous system of patients who died in the first 28 days of life were submitted to histological and immunohistochemistry analysis to identify the tissue immunoexpression of those biomarkers related to asphyxia, prematurity, and death events within 24h. Results: A significantly increased tissue immunoexpression of NF-kB, AKT-3 and Parkin was observed in the germinal matrix of preterm infants. In addition, significantly decreased tissue immunoexpression of VEGFR-1 and NF-kB was observed in patients who experienced asphyxia followed by death within 24 hours. Conclusions: The results suggest a direct involvement between the hypoxic-ischemic insult and NF-kB and VEGFR-1 markers since a decreased immunoexpression of these biomarkers was observed in asphyxiated patients. Furthermore, it is suggested that there was not enough time for VEGFR-1 to be transcribed, translated and expressed on the surface of the plasma membrane. This temporality can be observed in the relationship between NF-kB expression and the survival time of individuals who died within 24 hours, suggesting that this factor is essential for the production of VEGFR-1 and, therefore, to carry out the necessary remodeling effect to neovascularize the affected region.

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