2006
DOI: 10.1590/s1806-37132006000400011
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Abstract: The most useful immunohistochemical markers were was calretinin (for mesothelioma) and CEA (for adenocarcinoma). Immunohistochemical quantification of thrombomodulin facilitated the diagnosis of mesothelioma in patients testing positive for both calretinin and CEA. The most useful prognostic information was that provided by the routine histopathological analysis of the tumor type. It is of note that the combination of a mean age of 55 years and 30.5% immunohistochemical markers in nuclear components created a … Show more

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Cited by 4 publications
(18 citation statements)
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References 18 publications
(18 reference statements)
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“…Therapeutic options for a single treatment modality for MPM, such as chemotherapy, radiation, surgery, immunotherapy, or palliative procedures, have not shown good results, with survival rates from 6–20 months from diagnosis [23,33,34,35]. More promising results have been obtained using a combination of chemo- and immunotherapy [6,7,9,14].…”
Section: Discussionmentioning
confidence: 99%
“…Therapeutic options for a single treatment modality for MPM, such as chemotherapy, radiation, surgery, immunotherapy, or palliative procedures, have not shown good results, with survival rates from 6–20 months from diagnosis [23,33,34,35]. More promising results have been obtained using a combination of chemo- and immunotherapy [6,7,9,14].…”
Section: Discussionmentioning
confidence: 99%
“…Stromal cells, once seen as passive structural components of the tumor infrastructure, are now viewed as dynamic components of tumor initiation, progression, and invasion (Mueller and Fusenig, 2004; Tlsty and Coussens, 2006; Pietras and Ostman, 2010). Invasive tumors are composed of a large proportion of stroma; in MPM this proportion can be as high as 34–45% depending on the histologic subtype (Motta et al, 2006). The proportion is highest in biphasic and sarcomatoid tumors, the latter of which is associated with even worse prognosis than other subtypes (Motta et al, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…Invasive tumors are composed of a large proportion of stroma; in MPM this proportion can be as high as 34–45% depending on the histologic subtype (Motta et al, 2006). The proportion is highest in biphasic and sarcomatoid tumors, the latter of which is associated with even worse prognosis than other subtypes (Motta et al, 2006). This tumor-stroma balance creates a heterogeneous microenvironment composed of, among other things, malignant cells, cancer-associated fibroblasts, vascular endothelial cells, macrophages, and other inflammatory infiltrates.…”
Section: Introductionmentioning
confidence: 99%
“…( 22 ) In addition to the abovementioned epidemiological study, ( 23 ) studies have been conducted in Brazil in an attempt to improve the diagnosis of MM ( 25 , 26 ) and find prognostic markers of MM. ( 27 )…”
Section: Introductionmentioning
confidence: 99%
“…( 22 ) Além daquele estudo de cunho epidemiológico, ( 23 ) outros esforços científicos brasileiros foram realizados na busca por melhorias no diagnóstico ( 25 , 26 ) e por marcadores de prognóstico do MM. ( 27 )…”
Section: Introductionunclassified