Mapping the pharmaceutical design space by amorphous ionic liquid strategies

Wiest, Johannes; Saedtler, Marco; Balk, Anja; Merget, Benjamin; Widmer, Toni; Bruhn, Heike; Raccuglia, Marc; Elbast, Walid; Picard, Franck; Stopper, H. R.; Dekant, W.; Lühmann, Tessa; Sotriffer, Christoph A.; Galli, Bruno; Holzgrabe, Ulrike; Meinel, Lorenz

doi:10.1016/j.jconrel.2017.10.040

Cited by 31 publications

(14 citation statements)

References 43 publications

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“…An example of increasing absorption is the production of new salts of active substances, which can easily transfer through skin barriers. Such salts have an ionic liquid character (Wiest et al 2017;Egorova and Ananikov 2018). For example, diclofenac can be synthetized as a diethylamine salt with high bio-availability (dermal delivery) (Goh and Lane 2014).…”

Section: Design and Production Of Pharmaceuticalsmentioning

confidence: 99%

How to decrease pharmaceuticals in the environment? A review

Caban

Stepnowski

2021

Environ Chem Lett

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The global problem of the presence of human and veterinary pharmaceuticals in the environment is under investigation. Despite the increase in the knowledge of its sources, fates and impacts, the assessment of risks and the derived prevention actions are limited to single cases. The predicted increasing trend in the usage of pharmaceuticals forces the various parties involved to think about comprehensive mitigation actions. There are many areas of daily human life and industrial operations where such actions should take place. Thereby, in the presented review, such actions were summarized and divided into the following groups: A. design, synthesis and production of pharmaceuticals, B. prescription, sales and waste handling, C. control of the sources with advanced technologies. As the total amount of proposed actions was found to be quite high, a ranking according to the term of effects was proposed using the pyramid of needs. The advantages of actions taken in the first steps of the pharmaceutical life cycle (acting on the upstream) over end-of-pipe actions and the application of advanced technologies (the downstream option) were discussed, with reference to expert opinions.

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Section: Design and Production Of Pharmaceuticalsmentioning

confidence: 99%

How to decrease pharmaceuticals in the environment? A review

Caban

Stepnowski

2021

Environ Chem Lett

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“…By tuning the structure of the IL, researchers were able to control release based on NO uptake into the IL-drug system. [89] More recently, ILs have been applied as transport enhancers in drug delivery applications, [90] where their interactions with the barrier tissues have enabled the delivery of large molecules through otherwise formidable barriers. Banerjee and coworkers [91] delivered insulin orally using a choline geranate based ionic liquid, which maintains the secondary structure and activity of the insulin.…”

Section: Drug Deliverymentioning

confidence: 99%

Recent Advances in Ionic Liquids in Biomedicine

2021

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The use of ionic liquids and deep eutectic solvents in biomedical applications has grown dramatically in recent years due to their unique properties and their inherent tunability. This review will introduce ionic liquids and deep eutectics and discuss their biomedical applications, namely solubilization of drugs, creation of active pharmaceutical ingredients, delivery of pharmaceuticals through biological barriers, stabilization of proteins and other nucleic acids, antibacterial agents, and development of new biosensors. Current challenges and future outlooks are discussed, including biocompatibility, the potential impact of the presence of impurities, and the importance of understanding the microscopic interactions in ionic liquids in order to design task-specific solvents.

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“…The water-soluble acidic active pharmaceutical ingredients such as diclofenac, ibuprofen, ketoprofen, naproxen, sulfadiazine, sulfamethoxazole, and tolbutamide were converted into tetrabutylphosphonium ionic liquids and the results were quite encouraging compared with their respective free acid forms (Balk et al, 2015). A library of 36 counter ions as halide salts was prepared to map the pharmaceutical design space for ionic liquid of Selurampanel (Wiest et al, 2017).…”

Section: Ionic Liquidsmentioning

confidence: 99%

Oral Drug Delivery Technologies—A Decade of Developments

Kaur

Arora

Kumar

2019

J Pharmacol Exp Ther

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Advanced drug delivery technologies, in general, enable drug reformulation and administration routes, together contributing to life-cycle management and allowing the innovator to maintain the product monopoly. Over the years, there has been a steady shift from mere life-cycle management to drug repurposingapplying delivery technologies to tackle solubility and permeability issues in early stages or safety and efficacy issues in the late stages of drug discovery processes. While the drug and the disease in question primarily drive the choice of route of administration, the oral route, for its compliance and safety attributes, is the most preferred route, particularly when it comes to chronic conditions, including pain, which is not considered a disease but a symptom of a primary cause. Therefore, the attempt of this review is to take a stock of the advances in oral delivery technologies that are applicable for injectable to oral transformation, improve risk-benefit profiles of existing orals, and apply them in the early discovery program to minimize the drug attrition rates.

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Mapping the pharmaceutical design space by amorphous ionic liquid strategies

Cited by 31 publications

References 43 publications

How to decrease pharmaceuticals in the environment? A review

How to decrease pharmaceuticals in the environment? A review

Recent Advances in Ionic Liquids in Biomedicine

Oral Drug Delivery Technologies—A Decade of Developments

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