volume 126, issue 8, P935-938 2015
DOI: 10.1182/blood-2015-04-641688
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Abstract: Key Points• Electron microscopy and hydrogen-deuterium exchange establish the C1 domain as the major binding site for the VWF D9D3 domain on FVIII.• Additional sites implicated in the FVIII-VWF interaction are located within the a3 acidic peptide and the A3 and C2 domains of FVIII.Association with the D9D3 domain of von Willebrand factor (VWF) stabilizes factor VIII (FVIII) in the circulation and maintains it at a level sufficient to prevent spontaneous bleeding. We used negative-stain electron microscopy (EM…

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