2017
DOI: 10.1111/aji.12652
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Abstract: In order to generate new hypotheses, sometimes a “systems” approach is needed. In this review I focus on the mitogen activated kinase p38 because it has been recently shown to play an important role in the developmental programing and senescence of normal and stressed reproductive tissues. What follows is an overview of 1) pathways of p38 activation and their involvement in basic biological processes 2) evidence that p38 is involved in the homeostasis of reproductive tissues 3) how focus on p38 can be incorpor… Show more

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Cited by 46 publications
(40 citation statements)
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“…Premature aging in response to OSinducing risk factors can be linked to PTB and pPROM. 22,23 Although there are 4 p38MAPK isoforms, the α and β isoforms are the proteins whose activities are associated with normal physiologic processes as well as major physiologic characteristics of diseases of inflammation and OS that include age-associated diseases. 12,19 Behavioral risk factors, environmental pollutants, and infection are some of the risk factors capable of generating this pathway.…”
Section: Introductionmentioning
confidence: 99%
“…Premature aging in response to OSinducing risk factors can be linked to PTB and pPROM. 22,23 Although there are 4 p38MAPK isoforms, the α and β isoforms are the proteins whose activities are associated with normal physiologic processes as well as major physiologic characteristics of diseases of inflammation and OS that include age-associated diseases. 12,19 Behavioral risk factors, environmental pollutants, and infection are some of the risk factors capable of generating this pathway.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, women who underwent spontaneous labor at term have an elevated amniotic fluid concentration of senescence-associated secretory phenotype (SASP) markers [granulocytes macrophage colony-stimulating factor, interleukin (IL)-6 and IL-8] 33 , a greater number of telomere fragments in the amniotic fluid 34 , and a shorter telomere length and reduced lamin B1 in the chorioamnionitic membranes, as well as an upregulation of p21 35 , compared to those who delivered at term without labor. Further, in the murine chorioallantoic membranes, the telomere length shortens as the presence of mitogen-activated kinase p38 (p38-MAPK) 36 , active TP53, and SA-β-gal activity increases gradually throughout gestation 37 .…”
Section: Introductionmentioning
confidence: 99%
“…Hence, we focused on the study of the expression of its related proteins by western blotting. As Figure 3a ( Arthur & Ley., 2013;Bonney, 2017;Duan et al, 2016;Peti & Page., 2013). Here, we found that the level of p-p38 was upregulated when CNE2 cells were exposed to various concentrations of PP-22.…”
Section: Discussionmentioning
confidence: 99%