volume 66, issue 5, P3125-3130 1992
DOI: 10.1128/jvi.66.5.3125-3130.1992
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Abstract: Neutralization of human immunodeficiency virus type 1 (HIV-1) infection with soluble CD4 (sCD4) can be achieved over a broad range of concentrations for different virus strains. Laboratory virus strains passaged in transformed T-cell lines are typically sensitive to sCD4 neutralization, whereas primary virus isolates require over 100-fold-higher sCD4 concentrations. Using recombinant viruses generated from a laboratory strain, HIV-lNLA,3, and a primary macrophagetropic strain, HIV-1JRFL5, we mapped a region of…

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