MAO Inhibitors from Natural Sources for Major Depression Treatment

Souza, Luisa Nunes; Neto, Jonas Ferro da Silva; Cirilo, Maria Vitória da Silva Paula; Albuquerque, Gabriel Sousa; Gomes, Clayson Moura; Borges, Leonardo Luiz; Taft, Carlton A.; Silva, Vinícius Barreto da

doi:10.1007/978-3-031-07622-0_17

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Cited by 2 publications

References 37 publications

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Drug-Like Properties of Copaiba Tree Oil-Resin Active Ingredients

da Silva Paula Cirilo,

Albuquerque,

Sousa

et al. 2023

Engineering Materials

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Drug-Like Properties of Copaiba Tree Oil-Resin Active Ingredients

da Silva Paula Cirilo,

Albuquerque,

Sousa

et al. 2023

Engineering Materials

View full text Add to dashboard Cite

Pyrazoline Derivatives as Promising MAO-A Targeting Antidepressants: An Update

Choudhary,

Kaur,

Singh

et al. 2024

CTMC

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Depression is one of the key conditions addressed by the Mental Health Gap Action Programme (mhGAP) of WHO that can lead to self-harm and suicide. Depression is associated with low levels of neurotransmitters, which eventually play a key role in the progression and development of mental illness. The nitrogen-containing heterocyclic compounds exhibit the most prominent pharmacological profile as antidepressants. Pyrazoline, a dihydro derivative of pyrazole, is a well-known five-membered heterocyclic moiety that exhibits a broad spectrum of biological activities. Many researchers have reported pyrazoline scaffold-containing molecules as potential antidepressant agents with selectivity for monoamine oxidase enzyme (MAO) isoforms. Several studies indicated a better affinity of pyrazoline-based moiety as (monoamine oxidase inhibitors) MAOIs. In this review, we have focused on the recent advancements (2019-2023) in the development of pyrazoline-containing derivatives exhibiting promising inhibition of MAO-A enzyme to treat depression. This review provides structural insights on pyrazoline-based molecules along with their SAR analysis, in silico exploration of binding interactions between pyrazoline derivatives and MAO-A enzyme, and clinical trial status of various drug molecules against depression. The in-silico exploration of potent pyrazoline derivatives at the active site of the MAOA enzyme will provide further insights into the development of new potential MAO-A inhibitors for the treatment of depression.

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MAO Inhibitors from Natural Sources for Major Depression Treatment

Cited by 2 publications

References 37 publications

Drug-Like Properties of Copaiba Tree Oil-Resin Active Ingredients

Drug-Like Properties of Copaiba Tree Oil-Resin Active Ingredients

Pyrazoline Derivatives as Promising MAO-A Targeting Antidepressants: An Update

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