Manufacturing and Study of Mechanical Properties, Structure and Compatibility with Biological Objects of Plates and Wire from New Ti-25Nb-13Ta-5Zr Alloy

Abstract

A Ti–25Nb–13Ta–5Zr alloy was produced and studied in this work, and plates and wires were made from this alloy. It is shown that the Ti–25Nb–13Ta–5Zr alloy has the required mechanical properties and a β-crystal phase. Microstructures were present on the surface of the alloy with a height of several hundred nm, located at a distance of 1.5–2 μm from each other. Ti–25Nb–13Ta–5Zr was superior to nitinol in terms of the formation of long-living reactive protein species and the generation of reactive oxygen species. Cell cultivation on Ti–25Nb–13Ta–5Zr alloy surfaces revealed a significant mitotic index (2%) and a small number of nonviable cells (<5%). The cells were actively attached and spread over the alloy. The biocompatibility of Ti–25Nb–13Ta–5Zr was verified by experiments on the implantation of the alloy in the form of plates and coiled wires. The surface morphology of the specimens after biological trials was not significantly altered. The experimental data we obtained suggest that Ti–25Nb–13Ta–5Zr is suitable for potential applications in biology and medicine.

Additive Production of a Material Based on an Acrylic Polymer with a Nanoscale Layer of Zno Nanorods Deposited Using a Direct Current Magnetron Discharge: Morphology, Photoconversion Properties, and Biosafety

“…It was found that cells growing on the TiNbTaZn medical alloy and on the AP-ZnO material have similar growth and development indicators. It should be noted that alloys based on TiNbTaZn are quite modern and advanced alloys [ 73 , 74 ]. It was shown that alloys based on TiNbTaZn have better characteristics than the widely used alloy nitinol [ 75 ].…”

Evaluating the Prospects of Ti-Base Lattice Infiltrated with Biodegradable Zn–2%Fe Alloy as a Structural Material for Osseointegrated Implants—In Vitro Study

“…Although Ti–6Al–4V alloy is widely used as a structural material for implants, sometimes it has the tendency to generate problems, such as stress shielding and cytotoxicity that is mainly attributed to the presence of vanadium. Hence, it should be pointed out that other Ti-base alloys are also being considered as of late, such as beta-type Ti–Nb–Zr–Mn alloys [ 15 ], Ti25Nb–13Ta–5Zr [ 16 ], and Ti–Al–Nb [ 17 ]. As for the infiltrated biodegradable metal, there are basically three common alternatives: Fe-base, Mg- base, and Zn-base alloys.…”

Synthesis and Characterization of a Novel Biocompatible Alloy, Ti-Nb-Zr-Ta-Sn

“…In low elastic modulus Ti-Nb-Sn alloys, the Sn content does not exceed 4 wt./wt.% [ 64 , 65 ]. In contrast, the Zr content of low elastic modulus Ti-Nb-Ta-Zr alloys (55–60 GPa) is in the range of 4.5–7.0 wt./wt.% [ 66 , 67 , 68 ], an example, Ti-29Nb-13Ta-4.6Zr ([Mo]eq = 10.7) [ 3 , 69 , 70 ]. A shortcoming of this alloy is its relatively high cost due to the high content of Ta.…”