Manipulation of Quercetin and Melatonin in the Down-Regulation of HIF-1α, HSP-70 and VEGF Pathways in Rat’s Kidneys Induced by Hypoxic Stress

Abstract

Hypoxia may lead to inflammatory responses by numerous signaling pathways. This investigation intended to inspect the defensive role of Quercetin (Quer) and/ or Melatonin (Mel) against reno toxicity induced by Sodium nitrite (Sod ntr). Sod ntr injection significantly decreased blood hemoglobin concentration (Hb) with a concurrent increase in serum tumor necrosis factor- α, interleukin-6, C-reactive protein, creatinine, and urea levels. Over protein-expression of vascular endothelial growth factor and heat shock, protein-70 and mRNA of HIF-1α were also observed. Pretreatment of the Sod ntr- injected rats with the aforementioned antioxidants; either alone or together significantly improved such parameters. Histopathological examination reinforced the previous results. It was concluded that the combined administration of Quer and Mel may be useful as a potential therapy against renal injury induced by Sod ntr. HIF-1α and HSP-70 are implicated in the induction of hypoxia and its treatment.

Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines

“…Specifically, with the development of industrial technology and the progress of science and technology, the damage of chemical raw materials to the kidney has grown immensely prominent. Data from animal models have shown that the protective effect of quercetin is closely related to the clearance of free radicals and reduction of lipid peroxidation in both industrial chemical raw materials and heavy metal and diesel particulate pollution (Li et al, 2016b;Qi et al, 2017;Uthra et al, 2017;Alshanwani et al, 2020;Morsi et al, 2022). Moreover, Quercetin was also found to reduce organophosphorus pesticide mixture-induced nephrotoxicity by regulating fatty acid, energy and sex hormone metabolism, protecting antioxidant defense systems and reducing DNA damage (Qi et al, 2017).…”

Effect of Quercetin on Injury to Indomethacin-Treated Human Embryonic Kidney 293 Cells

“…Quercetin has therapeutic potential in cases of renal damage [91,92]. Previous studies have concluded that quercetin may effectively treat renal injury caused by chemical compounds that induce hypoxia [30,32,93,94]. In the present study, we used quercetin as a natural agent to reduce indomethacin-induced renal injury.…”

Research progress of melatonin (MT) in improving ovarian function: a review of the current status

“…Giving exogenous MT at the same time of the day can trigger physiological and behavioral rhythms (such as body temperature and rest-activity cycles) [ 80 ]. According to previous reports, MT can regulate a variety of biological functions, including the vision, neuroendocrine, reproduction, neuroimmunity, and vascular physiology [ 13 , 81 – 84 ]. Since the MT secretion is proportional to the night length, MT also presents a regular seasonal change cycle.…”