Manipulation of process parameters to achieve different ternary phase microparticle configurations

Lee, Wei‐Li; Foo, Wan Ling; Widjaja, Effendi; Loo, Say Chye Joachim

doi:10.1016/j.actbio.2009.10.028

Cited by 27 publications

(24 citation statements)

References 31 publications

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“…In contrast, tri‐layered structure resulted when viscosity of PLGA was <<1.1 (Systems S2 and S3) and initial polymer concentrations were kept above cloud point keeping all other parameters same as System S1. Probably due to considerably lower viscosity and also more compatibility between DCM and PLGA compared to PLLA, more quantity of DCM may partition into PLGA phase. As a result of which, PLGA phase with more DCM content, may become more hydrophobic than PLLA–DCM droplet leading to the migration of PLGA–DCM droplet toward core and relatively hydrophilic PLLA–DCM droplet toward shell being attracted by surrounding aqueous PVA solution.…”

Section: Resultssupporting

confidence: 50%

“…This layer configuration can be reversed if mass ratios are also altered . In various articles, they have also reported the fabrication of ternary‐phase microparticles having PLGA core and PLLA shell impregnated with poly(ε‐caprolactone) particulates by changing the polymer content . The influences of these ternary phases on drug release have also been evaluated .…”

Section: Introductionmentioning

confidence: 99%

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New insight into the mechanism of formation of dual actives loaded multilayered polymeric particles and their application in food preservation

Biswal¹,

Saha²

2019

J of Applied Polymer Sci

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This study provides an insight about the mechanism of formation of tri‐layered (instead of bilayers) particles originated from two biodegradable polymers by emulsion solvent evaporation method. It was also demonstrated how layer configurations of tri‐layered particles composed of poly(l‐lactide) (PLLA) and poly(d,l‐lactide‐co‐glycolide) (PLGA), can be changed from kinetically trapped to thermodynamically favorable structures (dictated by spreading coefficient theory) by tweaking several solution parameters. Layer switching, core, and shell thickness manipulation can also be achieved. Interestingly, among the various configurations, tri‐layered particles made with PLGA of intermediate viscosity and PLLA of high viscosity were found to provide controlled and sustainable release profiles for dual actives such as antibacterial (benzoic acid) and antioxidant (tocopherol) with appreciably high release rates. The dual activity of these particles was tested by incorporating them in chicken broth medium and found to provide excellent antibacterial as well as antioxidant activity for extended period of time (>20 days). © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48009.

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Section: Resultssupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

New insight into the mechanism of formation of dual actives loaded multilayered polymeric particles and their application in food preservation

Biswal¹,

Saha²

2019

J of Applied Polymer Sci

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“…Proper drug administration requires a fine balance between time, dosage, and mode of delivery, and, more importantly, should aid in improving patient compliance and clinical outcomes. These factors have consequently led to the emergence of various drug delivery systems, such as liposomes, micelles, emulsions and micro/nanoparticles 7–12. However, monolithic particulate systems may suffer from burst release due to the presence of undissolved drug trapped on the particle surface.…”

Section: Methodsmentioning

confidence: 99%

Microencapsulation of Dye‐ and Drug‐Loaded Particles for Imaging and Controlled Release of Multiple Drugs

Khung

Lee

Chui

et al. 2012

Adv Healthcare Materials

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“…Researchers are exerting efforts to widen the usage of this polymer, by copolymerizing with PLLA, PDLLA, PLGA, and so on. These copolymers should enhance degradation kinetics in drug delivery (21)(22)(23)(24). PCL composites have been used more in tissue engineering and medical implants compared to drug delivery (1).…”

Section: Poly(α-hydroxy Acids)mentioning

confidence: 98%

Biodegradable Polymers: Medical Applications

Kunduru

Basu

Domb

2016

Encyclopedia of Polymer Science and Technology

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Biodegradable polymers are the “green materials” of the future. They break down into smaller chemical fragments and are finally eliminated from the body. Biodegradable polymers have been used for more than 50 years with diverse applications such as surgical sutures, wound dressings, tissue regeneration, enzyme immobilization, controlled drug delivery and gene delivery, tissue engineering scaffold, cryopreservation, nanotechnology, medical implants and devices, prosthetics, augmentation, cosmetics, sanitation products, coatings, adhesives, and many more. This article reviews synthetic (esters, amides, ethers, urethanes) and natural (polysaccharides and proteins) biodegradable polymers, highlighting their biomedical applications.

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Manipulation of process parameters to achieve different ternary phase microparticle configurations

Cited by 27 publications

References 31 publications

New insight into the mechanism of formation of dual actives loaded multilayered polymeric particles and their application in food preservation

New insight into the mechanism of formation of dual actives loaded multilayered polymeric particles and their application in food preservation

Microencapsulation of Dye‐ and Drug‐Loaded Particles for Imaging and Controlled Release of Multiple Drugs

Biodegradable Polymers: Medical Applications

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