Manipulación de lesiones en pacientes con leishmaniasis cutánea: serie de casos en un hospital peruano

Pineda-Reyes, Juan; Marín, Ricardo; Tinageros-Zevallos, Andrea; Ramos, Ana Pilar; Alvarez, Fiorela; Llanos‐Cuentas, Alejandro

doi:10.17843/rpmesp.2020.372.4799

Cited by 2 publications

(1 citation statement)

References 9 publications

(22 reference statements)

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“…Microscopy of Giemsa-stained smear taken by skin scraping or needle aspiration is the most commonly used method for CL diagnosis. However, it has poor sensitivity [ 18 , 19 ] that lies between 15 and 83% depending on the reference test used [ 15 , 20 , 21 ], duration of the lesion [ 21 ], parasite load [ 22 ], examiner expertise [ 23 ], and the prior use of treatments [ 24 ]. In addition, sampling causes pain, bleeding, and scars [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of CL Detect rapid-immunochromatographic test for cutaneous leishmaniasis: a systematic review and meta-analysis

Gebremeskele,

Adane,

Adem

et al. 2023

Syst Rev

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Background Sensitive, robust, and fast point-of-care tests are needed for cutaneous leishmaniasis (CL) diagnosis. The recently developed CL Detect rapid test (InBios) for detecting Leishmania peroxidoxin antigen has been evaluated in several studies. However, diagnostic performances were controversial. Therefore, this systematic review and meta-analysis aimed to determine the pooled sensitivity and specificity of CL Detect for CL diagnosis. Methods PubMed, Scopus, EMBASE, ScienceDirect, and Google Scholar were sources of articles. We included studies reporting the diagnostic accuracy of CL Detect and CL-suspected patients in the English language. The methodological qualities of the included studies were appraised using the quality assessment of diagnostic accuracy studies-2 (QUADAS‐2). Meta-analysis was conducted using Stata 14.2 and R software. Results A total of 9 articles were included. The study sample size ranged from 11 to 274. The sensitivities of the individual studies ranged from 23 to 100%, and the specificities ranged from 78 to 100%. Pooled sensitivity and specificity were 68% (95% CI, 41–86%) and 94% (95% CI, 87–97%), respectively. AUC displayed 0.899. Pooled sensitivity was lower (47%, 95% CI, 34–61%) when PCR was used as a reference than microscopy (83%, 95% CI, 39–97%). Pooled sensitivity was lower (48%, 95% CI, 30–67%) for all lesion durations compared to ≤ 4 months (89%, 95% CI, 43–99%). Conclusions CL Detect has poor sensitivity and does not meet the minimal sensitivity of 95% of target product profiles designed for CL point-of-care tests. Currently, the CL Detect test looks unsuitable for CL diagnosis, despite its high specificity. Findings are limited by the low number of studies available. Further large-scale studies are recommended. Systematic review registration PROSPERO CRD42022323497.

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Section: Introductionmentioning

confidence: 99%

Diagnostic performance of CL Detect rapid-immunochromatographic test for cutaneous leishmaniasis: a systematic review and meta-analysis

Gebremeskele,

Adane,

Adem

et al. 2023

Syst Rev

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Estudio clínico y epidemiológico de Leishmaniasis Cutánea en un Hospital Nivel II Del Perú

et al. 2021

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Objetivo: Determinar la identificación de caracteres epidemiológicos y clínicos proveniente de casos de leishmaniosis cutánea del Hospital de Tingo María (HTM), Leoncio Prado, Huánuco 2017–2020. Metodología: Estudio descriptivo, se llevó a cabo en base a la información recabada de las historias clínicas y epidemiológicas de los pacientes diagnosticados con leishmaniosis cutánea del HTM. Resultados: Se reportó prevalencia en las etapas joven (30,8%) y adulto (30,8%). El 84,6% de los casos fueron de sexo masculino. El 92,3% de los casos no presentaron antecedentes de la enfermedad, 61,5% de los pacientes realizaron pruebas de descarte de la enfermedad entre 3 a 6 meses. El distrito de Rupa Rupa (66,7%) presentó mayor cantidad de casos. Localizándose mayormente en el miembro inferior (46,2%) y el miembro superior (34,6%). La sintomatología y signos más comunes fue el dolor en la lesión con 92,3% y el prurito local con 96,2%; y la forma de diagnóstico fue el frotis en el 100% de los casos. Conclusiones: Aunque la incidencia de leishmaniasis cutánea reportados por el HTM ha disminuido últimamente; continúa persistiendo como una problemática en la salud de la población en esta región del Perú.

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Manipulación de lesiones en pacientes con leishmaniasis cutánea: serie de casos en un hospital peruano

Cited by 2 publications

References 9 publications

Diagnostic performance of CL Detect rapid-immunochromatographic test for cutaneous leishmaniasis: a systematic review and meta-analysis

Diagnostic performance of CL Detect rapid-immunochromatographic test for cutaneous leishmaniasis: a systematic review and meta-analysis

Estudio clínico y epidemiológico de Leishmaniasis Cutánea en un Hospital Nivel II Del Perú

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