Abstract:As one of the leading cases of acute liver failure triggered by excessive acetaminophen (APAP), breakdown of the antioxidant system, inflammatory response, and inescapable apoptosis following overaccumulation of reactive oxygen...
“…Pretreatment with nano PB intravenously reduced oxidative stress by activating the Nrf2 pathway, reducing the expression of peroxidase and F480 in the liver and counteracting inflammation, to maintain the normal microenvironment of the liver, thereby preventing drug-induced liver damage. 45,46…”
Section: Expansion Of This Proposed Preventivementioning
Metrics & MoreArticle Recommendations CONSPECTUS: Nanomedicine is an interdisciplinary science that involves chemistry, materials, physics, engineering, biology, and medicine. The main focus of nanomedicine is on drug carriers: how to improve drug efficacy and reduce side effects. In order to further improve the synergistic and detoxifying effects of nanomedicines, scientists have adopted a multifunctional integration strategy. However, versatility brings complex components and ignores the synergistic effects between components. The lack of in-depth research on the bioactivities of nanocarriers hinders the development and clinical translation of nanomedicine.In the past decade, scientists have gradually discovered that nanomaterials show excellent bioactivities, becoming an enormous treasure trove for disease prevention and treatment. Among numerous bioactive materials, Prussian blue (PB) is a clinical antidote approved by the US Food and Drug Administration, showing excellent biosafety. However, clinically approved PB owns many drawbacks, and it is difficult to satisfy the requirements of disease prevention and treatment. When the size reduces to the nanoscale, nano PB shows both unique properties of nanomaterials and the enhancement of its performance and bioactivities. Due to its easy-to-regulate structure and rich iron suspended bonds, nano PB may be a potential drug delivery system. Electron transition in the Fe-CN-Fe structure endows nano PB with strong absorbance in the near-infrared region, becoming a potential photothermal conversion agent. Furthermore, due to its rich redox potential and catalytic activities, nano PB may be a bioactive drug with a great translational clinic prospect.In this Account, we describe our exploration of nano PB as a photothermal conversion agent, a drug delivery system and a bioactive drug in the prevention and treatment of disease over the past decade. We first summarize the application of nano PB as a photothermal conversion agent and a drug delivery system in the treatment of cancer, and then focus on our recent progress in the application of nano PB as a bioactive drug in the prevention and treatment of diseases (such as tumors, neurodegeneration, cerebrovascular disease, bone-related degenerative disease, gastrointestinal disease, and skin lesions). Finally, we look forward to the open challenges and future developments in this rapidly developing field. We hope this Account will help readers understand nano PB not only as a photothermal conversion agent and drug carrier but also as a bioactive drug, thus realizing its great potential in disease prevention and treatment. These studies also provide a research paradigm for bioactive nanomaterials. As our and other teams continue to explore this promising material, the unique characteristics of bioactive nanomaterials represented by nano PB may bring further exciting developments in disease prevention and treatment.
“…Pretreatment with nano PB intravenously reduced oxidative stress by activating the Nrf2 pathway, reducing the expression of peroxidase and F480 in the liver and counteracting inflammation, to maintain the normal microenvironment of the liver, thereby preventing drug-induced liver damage. 45,46…”
Section: Expansion Of This Proposed Preventivementioning
Metrics & MoreArticle Recommendations CONSPECTUS: Nanomedicine is an interdisciplinary science that involves chemistry, materials, physics, engineering, biology, and medicine. The main focus of nanomedicine is on drug carriers: how to improve drug efficacy and reduce side effects. In order to further improve the synergistic and detoxifying effects of nanomedicines, scientists have adopted a multifunctional integration strategy. However, versatility brings complex components and ignores the synergistic effects between components. The lack of in-depth research on the bioactivities of nanocarriers hinders the development and clinical translation of nanomedicine.In the past decade, scientists have gradually discovered that nanomaterials show excellent bioactivities, becoming an enormous treasure trove for disease prevention and treatment. Among numerous bioactive materials, Prussian blue (PB) is a clinical antidote approved by the US Food and Drug Administration, showing excellent biosafety. However, clinically approved PB owns many drawbacks, and it is difficult to satisfy the requirements of disease prevention and treatment. When the size reduces to the nanoscale, nano PB shows both unique properties of nanomaterials and the enhancement of its performance and bioactivities. Due to its easy-to-regulate structure and rich iron suspended bonds, nano PB may be a potential drug delivery system. Electron transition in the Fe-CN-Fe structure endows nano PB with strong absorbance in the near-infrared region, becoming a potential photothermal conversion agent. Furthermore, due to its rich redox potential and catalytic activities, nano PB may be a bioactive drug with a great translational clinic prospect.In this Account, we describe our exploration of nano PB as a photothermal conversion agent, a drug delivery system and a bioactive drug in the prevention and treatment of disease over the past decade. We first summarize the application of nano PB as a photothermal conversion agent and a drug delivery system in the treatment of cancer, and then focus on our recent progress in the application of nano PB as a bioactive drug in the prevention and treatment of diseases (such as tumors, neurodegeneration, cerebrovascular disease, bone-related degenerative disease, gastrointestinal disease, and skin lesions). Finally, we look forward to the open challenges and future developments in this rapidly developing field. We hope this Account will help readers understand nano PB not only as a photothermal conversion agent and drug carrier but also as a bioactive drug, thus realizing its great potential in disease prevention and treatment. These studies also provide a research paradigm for bioactive nanomaterials. As our and other teams continue to explore this promising material, the unique characteristics of bioactive nanomaterials represented by nano PB may bring further exciting developments in disease prevention and treatment.
“…Therefore, utilizing PB NPs to scavenge overexpressed ROS can prevent and treat inflammatory diseases such as inflammatory bowel disease, pancreatitis, atherosclerosis, and hepatitis, cerebrovascular diseases. [161][162][163][164] Before the PB NPs can be applied to the clinical treatment of cardiovascular disease, infection and inflammation, the mechanism of action needs to be further studied. 57,165,166 (4) Simplify the design and integration of nanoplatforms.…”
Malignant tumours are a serious threat to human health. Traditional chemotherapy has achieved breakthrough improvements but also has significant detrimental effects, such as the development of drug resistance, immunosuppression, and...
“…Moreover, Chen et al have successfully prepared multi-functional manganese Prussian blue nanozymes (MPBZs) with excellent ROS-scavenging capacity for the efficient treatment of APAP-induced liver injury by undergoing sequential processes ranging from antioxidation to anti-inflammation, including Nrf2 signaling pathway activation, inhibition of mitochondrial-induced oxidative stress and inflammation regulation. 78…”
Section: Fe-based Nanozymesmentioning
confidence: 99%
“…Moreover, Chen et al have successfully prepared multi-functional manganese Prussian blue nanozymes (MPBZs) with excellent ROS-scavenging capacity for the efficient treatment of APAP-induced liver injury by undergoing sequential processes ranging from antioxidation to anti-inflammation, including Nrf2 signaling pathway activation, inhibition of mitochondrial-induced oxidative stress and inflammation regulation. 78 Figure 3 Fe-based nanozymes for ALI alleviation. ( A ) Schematic illustrations of PB nanozymes preventing anthracycline-induced liver injury by attenuating oxidative stress and regulating inflammation.…”
Section: Ros-scavenging Nanozymes For Ali Alleviationmentioning
Acute liver injury (AIL), a fatal clinical disease featured with a swift deterioration of hepatocyte functions in the short term, has emerged as a serious public health issues that warrants attention. However, the effectiveness of existing small molecular antioxidants and anti-inflammatory medications in alleviating AIL remains uncertain. The unique inherent structural characteristics of liver confer it a natural propensity for nanoparticle capture, which present an opportunity to exploit in the formulation of nanoscale therapeutic agents, enabling their selective accumulation in the liver and thereby facilitating targeted therapeutic interventions. Significantly increased reactive oxygen species (ROS) accumulation and inflammation response have been evidenced to play crucial roles in occurrence and development of AIL. Nanozymes with ROS-scavenging capacities have demonstrated considerable promise in ROS elimination and inflammation regulation, thereby offering an appealing therapeutic instrument for the management of acute liver injury. In this review, the mechanisms of different type of ALI were summarized. In addition, we provide a comprehensive summary and review of the available ROS-scavenging nanozymes, including transition metal-based nanozymes, noble metal nanozymes, carbon-based nanozymes, and some other nanozymes. Furthermore, the challenges still need to be solved in the field of ROSscavenging nanozymes for ALI alleviation are also discussed.
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