Manfaat Xanthone Terhadap Kesembuhan Ulkus Rongga Mulut Dilihat Dari Jumlah Sel PMN Dan Fibroblast

Sunarjo, Lanny; Hendari, Ratnawati; Rimbyastuti, Hermien

doi:10.30659/odj.2.2.17-24

Cited by 16 publications

(18 citation statements)

References 5 publications

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“…Lesi ulkus traumatik dapat sembuh dengan sendirinya dalam waktu 10 hingga 14 hari apabila iritan atau penyebab dihilangkan karena dalam rentang waktu tersebut akan terjadi proses keratinisasi dan pembaharuan sel-sel epitel mukosa oral. 3 Penanganan ulkus traumatik yang utama ialah menghilangkan penyebab trauma dan pemberian obat antiinflamasi, seperti kortikosteroid topikal dan intralesi, juga anastetikum lokal. 2 Mengingat kejadian ulkus traumatik sering ditemukan dalam praktek sehari-hari maka penulis tertarik untuk membahas mengenai penyebab, tanda dan gejala, penampakan klinis, serta tatalaksana ulkus traumatik pada seorang pasien yang mengalami oklusi traumatik di RSGMP Universitas Jalan Sudirman (UNSOED) Purwokerto.…”

Section: Pendahuluanunclassified

Tata Laksana Perawatan Ulkus Traumatik pada Pasien Oklusi Traumatik: Laporan Kasus

Violeta¹,

Hartomo²

2020

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Traumatic oral ulcer is commonly caused by mucosal injury due to mastication or speaking, warm food or drink, sharp restoration surface, as well as partial broken restored tooth. We reported a case of traumatic oral ulcer in an 18-year-old female who was admitted to the RSGM Unsoed due to painfull sensation on the lesion. Objective examination revealed two lesions, as follows: tooth 47, painfull ulcer in buccal mucosa, solitary, whitish red, white border (punch-out), 4 mm in diameter; teeth 33 and 34, an irregular fissure, solitary, on the 2/3 posterior part of the tongue, 2 mm in depth, 1 cm in length, and not painfull. The diagnosis of this case was traumatic ulcer due to traumatic occlusion based on anamnesis, examination, and occlusion check using articulating paper on the nearest antagonistic tooth to the lesion. The treatment included Dental Health Education (DHE) concerning proper tooth brushing, topical triamci-nolone acetonide application for 5 days, dan selective grinding of teeth 17 and 47. After one-week follow-up, the ulcer had improved and no hyperemia, therefore, the patient could chew comfortably.Keywords: traumatic ulcer, traumatic occlusion, selective tooth grindingAbstrak: Ulkus traumatik biasanya disebabkan oleh tergigitnya dinding mukosa ketika makan atau berbicara, meminum dan memakan yang panas, permukaan restorasi gigi yang tajam, maupun adanya tumpatan yang pecah sebagian. Kami melaporkan kasus seorang perempuan berusia 18 tahun dengan kondisi ulkus traumatik datang ke RSGM Unsoed karena merasa terganggu dan perih pada bagian yang luka. Pada pemeriksaan objektif didapatkan pada gigi 47, lesi berupa ulkus pada area mukosa bukal, tunggal, berwarna merah keputihan, dengan peninggian pada tepi berwarna putih, nyeri, diameter 4 mm; dan pada gigi 33 dan 34, lesi berupa fisura memanjang, berbentuk iregular, tunggal, pada 2/3 dorsum lidah dengan kedalaman 2 mm, panjang 1 cm, tidak terasa nyeri. Diagnosis kasus ini ialah ulkus traumatik akibat oklusi traumatik berdasarkan anamnesis, pemeriksaan, dan cek oklusi menggunakan articulating paper pada gigi antagonis terdekat dengan lesi. Penatalaksanaan meliputi Dental Health Education (DHE) yaitu cara sikat gigi yang baik dan benar, pemberian triamcinolone acetonide topical selama 5 hari, dan selective grinding pada gigi 17 dan 47. Setelah satu minggu pada pengecekan didapatkan perbaikan ulkus dan tidak ditemukan pembengkakan sehingga pasien sudah nyaman untuk makan pada area tersebut.Kata kunci: ulkus traumatik, oklusi traumatik, selective grinding, trauma mekanik

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Section: Pendahuluanunclassified

Tata Laksana Perawatan Ulkus Traumatik pada Pasien Oklusi Traumatik: Laporan Kasus

Violeta¹,

Hartomo²

2020

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“…Ulkus merupakan suatu keadaan patologis yang menimbulkan kerusakan lapisan epitel dan jaringan dibawahnya atau hilangnya kontinuitas epitel serta membentuk cekungan yang berwarna putih kekuningan, jika ada peradangan ulkus dikelilingi lingkaran merah (1,2) . Prevalensi ulkus rongga mulut pada pasien yang berkunjung ke klinik gigi berkisar 26,4% -26,7% (3,4) , kejadian ulkus rongga mulut lebih banyak pada wanita berusia 16 -25 tahun dan pada usia dibawah 55 tahun (5,6) .…”

Section: Pendahuluanunclassified

Peranan Pasta Kulit Manggis Dalam Pembentukan Jaringan Ikat Kolagen Pada Proses Kesembuhan Ulkus Mukosa Mulut

Sunarjo

Siregar

Supriyana

2019

jkg. jurnal. kesehatan. gigi

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Prevalence of mouth ulcer in patients who visited dental clinic ranged 27%, contributing factors as chemical trauma and infection. Topical medicine available on the market today contained some chemicals might be contraindicated in hipersensitive patient, required an alternative medication of herbal ingredients that had same efficacy, safe and no allergic. Several studies had shown that xanthone contained in rind mangosteen could act as an anti inflammatory, anti bacterial and anti alergic. Aim of this study was to investigate application of rind mangosteen paste towards collagen formation in mouth ulcer healing due to chemical and infection. The experimental research with post test control group design, randomly obtained a total sample of male Wistar rats was 24 and divided into 4 groups @ 6 tails where 2 (two) treatment groups (due to chemical and infection) smeared with mangosteen rind paste and 2 (two) other treatment groups smeared with standard medicine (PVP), then from each group decapitated the 3 rd , 7 th and 10 th day. Observation was carried out macroscopically and microscopically then the data obtained on the 10 th day performed Kruskal Wallis test. The result of this study showed time healing for chemical ulcer was 9 days (standard medicine) and 10 days (mangosteen rind paste) while infectious ulcer was 10 days (standard medicine) and 9 days (mangosteen rind paste). Role of mangosteen rind paste proved significant in formation collagen of infectious ulcer, usage of standar medicine decreased area of collagen formation on 3 rd , 7 th and 10 th day (0,133 mm; 0,083 mm; 0,059 mm) while usage of mangosteen rind paste might increase this collagen formation (0,073 mm; 0,083 mm; 0,115 mm). There was significant difference broad of collagen formation with p value = 0,016. Topical usage of mangosteen rind paste might accelerate mouth ulcer healing and increase formation of collagen in infectious mouth ulcer.

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“…To date, effective RAS therapy has not been found, and its treatment is aimed at treating symptoms with a focus on suppressing local immune responses, reducing pain, discomfort, and preventing secondary infections and recurrences. If the ulcer is left unchecked, it will cause secondary infection because the oral cavity can be the ideal place for bacterial growth [2].…”

Section: Introductionmentioning

confidence: 99%

α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

et al. 2019

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Featured Application: This study highlights a novel application of α-mangostin hydrogel film based chitosan-alginate. α-mangostin has been known as an agent for oral cavity therapy. However, α-mangostin is difficult to be delivered directly to the site. This novel application of hydrogel film-based chitosan-alginate have the potential as carriers of α-mangostin for recurrent aphthous stomatitis therapy.Abstract: Many antiseptic drugs, local anaesthetics, and corticosteroids have been used for effective therapy of recurrent aphthous stomatitis (RAS). However, these drugs have harmful side effects. α-mangostin (α-M), a main compound of mangosteen (Garcinia mangostana L.) peel, has been known as a wound healing agent. In addition, hydrogel film as dressings designed to separate mucosal lesions from the oral environment, and improve the effectiveness of RAS therapy. The purpose of this study was to develop α-M hydrogel film based chitosan-alginate (ChAlg/α-M HF) for RAS. The in silico study by Discovery studio visualizer and AutoDock confirmed that hydrogen bonding between Ch, Alg, and α-M occurred. The results of physicochemical characterizations by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) indicated that the ChAlg/α-M HF had a lower crystalline form compared to pure α-M. In addition, ChAlg/α-M HF significantly improved the swelling ratio and tensile strength compared to that of ChAlg HF. Moreover, the existence of Alg increased the degradability of Ch, and closely related to the release of α-M from ChAlg HF. The in vitro release study confirmed that the release of α-M from ChAlg/α-M HF was the Fickian diffusion model. Finally, the mucoadhesive study revealed that ChAlg/α-M HF had a good mucoadhesive property. These results suggest that hydrogel film-based chitosan-alginate have the potential as carriers of α-M for RAS therapy.

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Manfaat Xanthone Terhadap Kesembuhan Ulkus Rongga Mulut Dilihat Dari Jumlah Sel PMN Dan Fibroblast

Cited by 16 publications

References 5 publications

Tata Laksana Perawatan Ulkus Traumatik pada Pasien Oklusi Traumatik: Laporan Kasus

Tata Laksana Perawatan Ulkus Traumatik pada Pasien Oklusi Traumatik: Laporan Kasus

Peranan Pasta Kulit Manggis Dalam Pembentukan Jaringan Ikat Kolagen Pada Proses Kesembuhan Ulkus Mukosa Mulut

α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

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