Mandibular defect repair by TGF-β and IGF-1 released from a biodegradable osteoconductive hydrogel

Srouji, Samer; Rachmiel, Adi; Blumenfeld, Israel; Livne, Erella

doi:10.1016/j.jcms.2004.09.003

Cited by 69 publications

(30 citation statements)

References 27 publications

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“…Different studies have been described in animal models with BMPs, PRPs or mesenchymal stem cells (Boyne, 2001;Srouji et al, 2005;Pradel et al, 2006;Carter et al, 2008;Pieri et al, 2009;Miloro et al, 2010;Mooren et al, 2010;Kazakos et al, 2011). At the moment however, these options are of experimental character and have to be further investigated in clinical trials.…”

Section: Discussionmentioning

confidence: 99%

Jaw cysts – Filling or no filling after enucleation? A review

Ettl

Gosau

Sader

et al. 2012

Journal of Cranio-Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Jaw cysts – Filling or no filling after enucleation? A review

Ettl

Gosau

Sader

et al. 2012

Journal of Cranio-Maxillofacial Surgery

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“…Unfortunately, few studies compared the growth factor combination versus single IGF and TGF-b controls and their experimental setup varied greatly, in particular with respect to dose and delivery vehicle (Table 4). [85][86][87][88] Compared to TGF-b alone, nanogram dosages of the IGF/TGF-b combination in solution or released from gelatin hydrogels did not result in significantly enhanced mechanical properties or bone formation in rat marginal cortical defects, tibial defects, and mandibular defects, but the release of micrograms of the growth factor combination from a coated titanium implant enhanced the mechanical properties and callus formation in a rat tibial fracture model (Table 4).…”

Section: Insulin-like Growth Factormentioning

confidence: 99%

Growth Factor Interactions in Bone Regeneration

Kempen

Creemers

Alblas

et al. 2010

Tissue Engineering Part B: Reviews

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Bone regeneration is a complex process regulated by a large number of bioactive molecules. Many growth factors and cytokines involved in the natural process of bone healing have been identified and tested as potential therapeutic candidates to enhance the regeneration process. Although many of these studies show an enhancement of the bone regeneration process by a single drug therapy, in vivo bone regeneration is the result of a complex interplay between the applied growth factor and various endogenous produced growth factors. To investigate these growth factor interactions, various studies have investigated the effect of growth factor combinations on bone regeneration. This review provides an overview of the growth factor and cytokine combinations tested in translational bone regeneration studies and shows that their interaction may result in an enhancement or inhibition of bone formation.

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“…There is now a solid evidence that these molecules will find many applications in the future (Srouji et al, 2005;Springer et al, 2008). Among these mediators, growth differentiation factor 5 (GDF-5) that belongs to the TGF-ß family, has received special attention because it plays a critical role in the early stages of development.…”

Section: Introductionmentioning

confidence: 99%