Management of Secretory Diarrhea

Velázquez, Claudia; Calzada, Fernando; Bautista, Mirandeli; Gayosso, Juan A.

doi:10.5772/28528

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…Medicinal plants and their bioactive molecules are always in demand and are a central point of research. As a result, there is a recent surge in the demand for herbal medicine [ 8 ]. Meanwhile, a range of medicinal plants with antidiarrheal properties is widely used by traditional healers, but still there is an urgent need for research on medicinal plant in the management of diarrheal diseases.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Antidiarrheal and Antimicrobial Activities of 80% Methanolic Leaf Extract of Discopodium Penninervum (Hochst.)

Derebe

Abdulwuhab

Wubetu

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Diarrhea is a major health problem throughout the world and it has become more problematic in developing countries like Ethiopia. People, in several parts of the world, use different traditional medicines for treating diarrhea and it has been reported that the roots, leaves, and flowers of various species are used for the same purpose. In Ethiopia, for instance, Discopodium Penninervum is used for the treatment of diarrhea and also to control infection. The aim of the present study was, therefore, to evaluate the in vivo antidiarrheal and in vitro antimicrobial effect of Discopodium Penninervum in mice. For the antimicrobial activity test, four standard bacteria and disc diffusion method were used, while for antidiarrheal experiment, animals had been used, which were divided into 5 groups. The first group served as negative control and was administered with vehicle (0.2-0.3ml of distilled water). Groups two (D100), three (D200), and four (D400) were administered 100, 200, and 400 mg/kg of the extract, respectively. Group five served as positive control group and was administered with either loperamide (3mg/kg) for castor oil induced diarrhea and castor oil induced enteropooling diarrhea models or atropine (1mg/kg) for charcoal meal test. Safety study was performed using a standard acute toxicity study procedure. The effect of the extract on castor oil induced diarrheal drops, onset of diarrhea, weight of faeces, small intestinal fluid accumulation, and intestinal motility was measured and analyzed using one-way ANOVA. Preliminary phytochemical screening of the leaves powder of the plant indicated the presence of various components. Inhibition of castor oil induced diarrhea was observed at all tested doses. It can be concluded that crude extracts of Discopodium Penninervum showed strong activities against diarrhea indicating that it contains some chemical constituents that possibly lead to antidiarrheal drug development.

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Section: Introductionmentioning

confidence: 99%

Investigation of the Antidiarrheal and Antimicrobial Activities of 80% Methanolic Leaf Extract of Discopodium Penninervum (Hochst.)

Derebe

Abdulwuhab

Wubetu

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…In Mexico, the use of medicinal plants for the treatment of gastrointestinal disorders including diarrhoea is also widespread. [117] Similarly, the methanolic and aqueous extracts of the plants Chiranthodendron pentadactylon, Hippocratea excela and Ocimum basilicum, the methanolic extract of Geranium mexicanum, the aqueous extract of Bocconia frutescens and plants used in Mexican popular medicine also presented antisecretory effects in rats. [118] In Poland, for centuries some species of plants belonging to the Rosaceae family: Agrimonia eupatoria L. (common agrimony), Fragaria vesca L. (wild strawberry), Rubus fruticosus L. (blackberry), Rubus idaeus L. (raspberry) and Rosa canina L. (rose) have been widely used as natural medicines for diarrhoea.…”

Section: Medicinal Plants As Sources Of Promising Compoundsmentioning

confidence: 99%

Section: Other Therapeutic Approachesmentioning

confidence: 99%

A comprehensive review of therapeutic approaches available for the treatment of cholera

Sousa

Nolêto

Chaves

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives The oral rehydration solution is the most efficient method to treat cholera; however, it does not interfere in the action mechanism of the main virulence factor produced by Vibrio cholerae, the cholera toxin (CT), and this disease still stands out as a problem for human health worldwide. This review aimed to describe therapeutic alternatives available in the literature, especially those related to the search for molecules acting upon the physiopathology of cholera. Key findings New molecules have offered a protection effect against diarrhoea induced by CT or even by infection from V. cholerae. The receptor regulator cystic fibrosis channel transmembrane (CFTR), monosialoganglioside (GM1), enkephalinase, AMP-activated protein kinase (AMPK), inhibitors of expression of virulence factors and activators of ADP-ribosylarginine hydrolase are the main therapeutic targets studied. Many of these molecules or extracts still present unclear action mechanisms. Conclusions Knowing therapeutic alternatives and their molecular mechanisms for the treatment of cholera could guide us to develop a new drug that could be used in combination with the rehydration solution.

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Management of Secretory Diarrhea

Cited by 2 publications

References 13 publications

Investigation of the Antidiarrheal and Antimicrobial Activities of 80% Methanolic Leaf Extract of Discopodium Penninervum (Hochst.)

Investigation of the Antidiarrheal and Antimicrobial Activities of 80% Methanolic Leaf Extract of Discopodium Penninervum (Hochst.)

A comprehensive review of therapeutic approaches available for the treatment of cholera

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