Management of Osteoarthritis

The Effect of Corticosteroid Doses on Pain in Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

“…Articles presenting randomized controlled trials (RCT) with at least one IACI and one normal saline group of intra-articular saline injections, and reporting outcomes related to pain intensity were included. Methylprednisolone or other corticosteroid with available equivalence (i.e., triamcinolone hexacetonide [TH]/acetonide [TA], betamethasone [BM]/dexamethasone sodium/acetate, or cortivazol [CZ] (Altman et al 2019;Douglas 2012;Jüni et al 2015;Michon et al 2010;Stephens et al 2008)) were included. Other corticosteroids (e.g., FX006) were excluded because there was no accepted equivalence.…”

“…Three dosing categories were used based on guideline recommendations (Brophy and Fillingham 2022;Kolasinski et al 2020). Usual dose was set at 40 mg of methylprednisolone (MP) dose-equivalent (corresponding to 40 mg of triamcinolone hexacetonide (TH)/acetonide (TA), 8 mg of betamethasone (BM)/dexamethasone sodium/acetate, and 3 mg of cortivazol (CZ)) (Altman et al 2019;Douglas 2012;Jüni et al 2015;Michon et al 2010;Stephens et al 2008).…”

The Effect of Corticosteroid Doses on Pain in Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

“…Articles presenting randomized controlled trials (RCT) with at least one IACI and one normal saline group of intra-articular saline injections, and reporting outcomes related to pain intensity were included. Methylprednisolone or other corticosteroid with available equivalence (i.e., triamcinolone hexacetonide [TH]/acetonide [TA], betamethasone [BM]/dexamethasone sodium/acetate, or cortivazol [CZ] (Altman et al 2019;Douglas 2012;Jüni et al 2015;Michon et al 2010;Stephens et al 2008)) were included. Other corticosteroids (e.g., FX006) were excluded because there was no accepted equivalence.…”

“…Three dosing categories were used based on guideline recommendations (Brophy and Fillingham 2022;Kolasinski et al 2020). Usual dose was set at 40 mg of methylprednisolone (MP) dose-equivalent (corresponding to 40 mg of triamcinolone hexacetonide (TH)/acetonide (TA), 8 mg of betamethasone (BM)/dexamethasone sodium/acetate, and 3 mg of cortivazol (CZ)) (Altman et al 2019;Douglas 2012;Jüni et al 2015;Michon et al 2010;Stephens et al 2008).…”

Attenuation of IL-1ß on the use of glucosamine as an adjuvant in meloxicam treatment in rat models with osteoarthritis

“…A measure of the success of OA therapy recommended by Outcome Measures in Rheumatology Clinical Trials (OMERACT) consists of four core categories, i.e., pain, physical function, general assessment by the patients, and general assessment by the doctors. Another key measure of success based on Disease-Modifying Osteoarthritis Drugs (DMOADs) is the narrowing of joint space, pain, and physical function [9].…”

Intraarticular applikation of polyacrylamide hydrogel as a treatment of osteoarthritis in the distal interphalangeal joint: case series with 12 horses

“…Bei Fehlen von röntgenologisch feststellbaren Veränderungen können mit Hilfe der Magnetresonanztomographie Knorpelveränderungen, subchondrale Knochenpathologien, vermehrte Gelenkfüllung sowie einer verdickten Gelenkskapsel dargestellt werden (Baxter et al 2011, Bell et al 2009, Sill 2007. Traditionell werden die Hufgelenke mit Hyaluronsäure, Glukokortikosteroiden und Polysulfatiertes Glykosaminoglykan (PSGAG) behandelt (Ferris et al 2011, Goldberg und Buckwalter 2005, Higgins und Lees 1984, Michon et al 2010, Mcllwraith 2010 (Christensen et al 2003, de Cassia Novaes und Berg 2003. Seit mehr als 10 Jahren wird PAAHG beim Menschen erfolgreich in der Plastischen und Ästhetischen Chirurgie als Weichteilfüller mit langanhaltendem Effekt eingesetzt (Breiting et al 2004, Yagi et al 2009).…”

The Effect of Corticosteroid Doses on Pain in Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

“…Articles presenting randomized controlled trials (RCT) with at least one IACI and one normal saline group of intra-articular saline injections, and reporting outcomes related to pain intensity were included. Methylprednisolone or other corticosteroid with available equivalence (i.e., triamcinolone hexacetonide [TH]/acetonide [TA], betamethasone [BM]/dexamethasone sodium/acetate, or cortivazol [CZ] (Altman et al 2019;Douglas 2012;Jüni et al 2015;Michon et al 2010;Stephens et al 2008)) were included. Other corticosteroids (e.g., FX006) were excluded because there was no accepted equivalence.…”

“…Three dosing categories were used based on guideline recommendations (Brophy and Fillingham 2022;Kolasinski et al 2020). Usual dose was set at 40 mg of methylprednisolone (MP) dose-equivalent (corresponding to 40 mg of triamcinolone hexacetonide (TH)/acetonide (TA), 8 mg of betamethasone (BM)/dexamethasone sodium/acetate, and 3 mg of cortivazol (CZ)) (Altman et al 2019;Douglas 2012;Jüni et al 2015;Michon et al 2010;Stephens et al 2008).…”

Attenuation of IL-1ß on the use of glucosamine as an adjuvant in meloxicam treatment in rat models with osteoarthritis

“…A measure of the success of OA therapy recommended by Outcome Measures in Rheumatology Clinical Trials (OMERACT) consists of four core categories, i.e., pain, physical function, general assessment by the patients, and general assessment by the doctors. Another key measure of success based on Disease-Modifying Osteoarthritis Drugs (DMOADs) is the narrowing of joint space, pain, and physical function [9].…”

Intraarticular applikation of polyacrylamide hydrogel as a treatment of osteoarthritis in the distal interphalangeal joint: case series with 12 horses

“…Bei Fehlen von röntgenologisch feststellbaren Veränderungen können mit Hilfe der Magnetresonanztomographie Knorpelveränderungen, subchondrale Knochenpathologien, vermehrte Gelenkfüllung sowie einer verdickten Gelenkskapsel dargestellt werden (Baxter et al 2011, Bell et al 2009, Sill 2007. Traditionell werden die Hufgelenke mit Hyaluronsäure, Glukokortikosteroiden und Polysulfatiertes Glykosaminoglykan (PSGAG) behandelt (Ferris et al 2011, Goldberg und Buckwalter 2005, Higgins und Lees 1984, Michon et al 2010, Mcllwraith 2010 (Christensen et al 2003, de Cassia Novaes und Berg 2003. Seit mehr als 10 Jahren wird PAAHG beim Menschen erfolgreich in der Plastischen und Ästhetischen Chirurgie als Weichteilfüller mit langanhaltendem Effekt eingesetzt (Breiting et al 2004, Yagi et al 2009).…”

The Effect of Corticosteroid Doses on Pain in Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

“…Articles presenting randomized controlled trials (RCT) with at least one IACI and one normal saline group of intra-articular saline injections, and reporting outcomes related to pain intensity were included. Methylprednisolone or other corticosteroid with available equivalence (i.e., triamcinolone hexacetonide [TH]/acetonide [TA], betamethasone [BM]/dexamethasone sodium/acetate, or cortivazol [CZ] (Altman et al 2019;Douglas 2012;Jüni et al 2015;Michon et al 2010;Stephens et al 2008)) were included. Other corticosteroids (e.g., FX006) were excluded because there was no accepted equivalence.…”

“…Three dosing categories were used based on guideline recommendations (Brophy and Fillingham 2022;Kolasinski et al 2020). Usual dose was set at 40 mg of methylprednisolone (MP) dose-equivalent (corresponding to 40 mg of triamcinolone hexacetonide (TH)/acetonide (TA), 8 mg of betamethasone (BM)/dexamethasone sodium/acetate, and 3 mg of cortivazol (CZ)) (Altman et al 2019;Douglas 2012;Jüni et al 2015;Michon et al 2010;Stephens et al 2008).…”

Attenuation of IL-1ß on the use of glucosamine as an adjuvant in meloxicam treatment in rat models with osteoarthritis

“…A measure of the success of OA therapy recommended by Outcome Measures in Rheumatology Clinical Trials (OMERACT) consists of four core categories, i.e., pain, physical function, general assessment by the patients, and general assessment by the doctors. Another key measure of success based on Disease-Modifying Osteoarthritis Drugs (DMOADs) is the narrowing of joint space, pain, and physical function [9].…”

Intraarticular applikation of polyacrylamide hydrogel as a treatment of osteoarthritis in the distal interphalangeal joint: case series with 12 horses

“…Bei Fehlen von röntgenologisch feststellbaren Veränderungen können mit Hilfe der Magnetresonanztomographie Knorpelveränderungen, subchondrale Knochenpathologien, vermehrte Gelenkfüllung sowie einer verdickten Gelenkskapsel dargestellt werden (Baxter et al 2011, Bell et al 2009, Sill 2007. Traditionell werden die Hufgelenke mit Hyaluronsäure, Glukokortikosteroiden und Polysulfatiertes Glykosaminoglykan (PSGAG) behandelt (Ferris et al 2011, Goldberg und Buckwalter 2005, Higgins und Lees 1984, Michon et al 2010, Mcllwraith 2010 (Christensen et al 2003, de Cassia Novaes und Berg 2003. Seit mehr als 10 Jahren wird PAAHG beim Menschen erfolgreich in der Plastischen und Ästhetischen Chirurgie als Weichteilfüller mit langanhaltendem Effekt eingesetzt (Breiting et al 2004, Yagi et al 2009).…”