Infectious Disease Clinics of North America volume 19, issue 4, P915-929 2005 DOI: 10.1016/j.idc.2005.08.001 View full text
Charalampos G. Zalavras, Michael J. Patzakis, Paul D. Holtom, Randy Sherman

Abstract: Open fractures are high-energy injuries that require a principle-based approach, starting with detailed evaluation of patient status and injury severity. Early, systemic, wide-spectrum antibiotic therapy should cover gram-positive and gram-negative organisms, and a common regimen is a 3-day administration of a first-generation cephalosporin and an aminoglycoside, supplemented with ampicillin or penicillin to cover anaerobes in farm or vascular injuries. Local antibiotic delivery with the bead pouch technique i…

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