Management of non-resectable (stage III) breast cancer

Prognostic Significance of Lymph Node Status in Stage III Breast Cancer

“…Consequently, the majority of these patients probably harbor micrometastases at the time of primary treatment. This has led many investigators to combine chemotherapy with surgery andlor irradiation as the initial treatment and enhanced recurrencefree interval and longer survival have been reported (1, 3, 6, 8, 11, 19,22,27,29,32,36).…”

Management of locally advanced breast cancer

“…A large number of studies in the literature report single arm trials using chemotherapy in combination with surgery, radio-therapy, or both, as well as retrospective reviews [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52]. The median time to progression varies from 21 to 30 months in these series, with 5-year relapse-free and overall survival being heavily dependent on stage subset.…”