Management of malignant sublingual salivary gland tumors

Rinaldo, Alessandra; Shaha, Ashok R.; Pellitteri, Phillip K.; Bradley, Patrick; Ferlito, Alfio

doi:10.1016/s1368-8375(03)00104-0

Cited by 73 publications

(54 citation statements)

References 16 publications

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“…Although the role of adjuvant RT in the treatment of salivary carcinomas has not been studied in a randomized, prospective cohort, several retrospective studies have shown increased local and local-regional control with adjuvant RT across various histologic subtypes and head and neck subsites [1][2][3][4][5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…Representing less than 5% of all new cancer diagnoses, multi-institutional, prospective studies are a challenge to perform. Standard of care, based primarily on single-institution retrospective series, involves surgery at the primary site followed by adjuvant radiotherapy (RT) for high-risk features such as high-grade histology or low-grade tumors that are multiply recurrent or have positive margins [1][2][3][4][5][6][7][8][9]. Although clinically or radiographically positive neck disease should undergo therapeutic neck dissection, the role for elective neck dissection remains limited as it is not indicated in low-grade malignancies; elective neck irradiation provides excellent control rates for high-grade or large (T3 or T4) tumors [10].…”

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confidence: 99%

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Outcomes after primary or adjuvant radiotherapy for salivary gland carcinoma

et al. 2016

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Background: We report long-term outcomes of patients treated with primary radiotherapy (RT) or surgery and adjuvant RT for salivary gland malignancies. Materials and methods: From 1964 to 2012, 291 patients received primary RT (n ¼ 67) or RT combined with surgery (n ¼ 224). Results: The 5-, 10-, and 15-year local control, local-regional control, distant metastasis-free survival, cause-specific survival and overall survival rates were 82%, 77% and 73%; 77%, 72% and 67%; 74%, 70% and 70%; 70%, 59% and 54%; and 63%, 47% and 38%, respectively. Per multivariate analysis, combined surgery and RT and T stage impacted local control; overall stage and combined surgery and RT impacted local-regional control; overall stage impacted distant metastasis-free survival; and overall stage, node positivity, clinical nerve invasion, and surgery and RT impacted cause-specific and overall survival. Five percent of patients experienced grade 3 or worse toxicity. Conclusion: Combined surgery and RT improves local control, local-regional control, and cause-specific survival compared with primary RT for salivary tumors.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Outcomes after primary or adjuvant radiotherapy for salivary gland carcinoma

et al. 2016

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“…In addition, it presents a strong neurotropism, which is a major route of tumor dissemination. (1) As far as the prevalence of ACC, it represents a quarter of malignant tumors of the salivary glands, both in the major and in the minor salivary glands, although more frequently located in the minor salivary glands, mainly at the roof of the mouth, which accounts for 31% of the lesions. (2) ACC usually appears between the third and ninth decade of life, with a peak incidence in patients between the ages of 40 and 70 years old; however, it does not appear to be predominant in any sex.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and treatment of adenoid cystic carcinoma of the minor salivary glands: A meta-analytic study

Martínez-Rodríguez¹,

Leco-Berrocal²,

Rubio-Alonso³

et al. 2011

Med Oral

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Objectives: To evaluate the epidemiological aspects of adenoid cystic carcinoma (ACC) and to evaluate the different therapeutic possibilities as well as the percentage of survival. Study Design: A retrospective, meta-analytic, observational study was carried out by selecting a total of 13 articles, which provided a sample size of 263 cases of patients who had been diagnosed with ACC in the minor salivary glands. Results: ACC was found to be more common among women (56.5%) and the average age at diagnosis was 55.26 years old. The primary location of the tumor was in the palate in 57% of the cases, the predominant pattern being cribiform. The treatment of choice was therapy combined with surgery and radiotherapy in 62.7% of the subjects. The overall survival rate was 70.76% and 56.76%, at 5 and 10 years respectively. Conclusions: Early detection of adenoid cystic carcinoma is necessary in order to enable making an earlier prognosis and thus enable a better quality of life for the patient.

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“…[7] A submucosal tumor-like lesion in the floor of the mouth may arise from the sublingual gland, the submandibular duct or adjacent minor salivary glands. Therefore, the differential diagnosis of a tumor in the sublingual gland area includes various salivary gland pathologic entities, such as benign and malignant neoplasms, and nonneoplastic entities (e.g.…”

Section: Discussionmentioning

confidence: 99%

Papillary cystadenocarcinoma of the sublingual gland: case report and literature review

Paschalidi¹,

Nikitakis²,

Igoumenakis³

et al. 2017

SDS

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Papillary cystadenocarcinoma (CAC) a rare malignant salivary gland tumor which commonly arises in the major glands, mainly the parotid, and less frequently in the minor salivary glands. Localization in the sublingual salivary gland is very rare. The authors present a case of papillary CAC originating from the right sublingual gland in a 78-year-old female. A review of the literature revealed only 3 previously published detailed cases (in addition to 2 cases as part of larger series) of papillary CAC of the sublingual gland. The salient demographic, clinical, and histopathologic findings of papillary CAC, as well as its surgical treatment, are discussed. Key words:Papillary cystadenocarcinoma, sublingual gland, cystic structures ABSTRACT Article history:

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Management of malignant sublingual salivary gland tumors

Cited by 73 publications

References 16 publications

Outcomes after primary or adjuvant radiotherapy for salivary gland carcinoma

Outcomes after primary or adjuvant radiotherapy for salivary gland carcinoma

Epidemiology and treatment of adenoid cystic carcinoma of the minor salivary glands: A meta-analytic study

Papillary cystadenocarcinoma of the sublingual gland: case report and literature review

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