MANAGEMENT OF ENDOCRINE DISEASE: Visual morbidity in patients with pituitary adenoma

Lithgow, Kirstie; Batra, Ruchika; Matthews, Tim; Karavitaki, Niki

doi:10.1530/eje-19-0349

Cited by 21 publications

(19 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the current management of pituitary adenomas, an optimal ophthalmological examination is paramount to ensure optimal timing of treatment [12]. Two main examinations for proper patient stratification are the evaluation of VFs and VA. As exemplified by Fig.…”

Section: Towards Clinical Benchmarking For Nfma Patients With Optic Chiasm Compressionmentioning

confidence: 99%

“…The clinical relevance of prevention of visual morbidity as a benchmark for quality of care in pituitary adenoma patients is highly acknowledged [12]. The aim of this manuscript is to provide clinical recommendations for timing of surgical decompression, based on best available evidence and with a new approach to use MD to improve objective reporting of VFDs severity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quality of care evaluation in non-functioning pituitary adenoma with chiasm compression: visual outcomes and timing of intervention clinical recommendations based on a systematic literature review and cohort study

et al. 2020

View full text Add to dashboard Cite

Purpose Surgery in patients with non-functioning pituitary macroadenomas (NFMA) is effective in ameliorating visual function. The urgency for decompression, and preferred timing of surgery related to the preoperative severity of dysfunction is unknown. Methods Systematic review for evidence to provide clinical guidance for timing of surgical decompression of the optic chiasm, and a cohort study of 30 NFMA patients, in whom mean deviation (MD), and severity of visual dysfunction was assessed. Results Systematic review 44 studies were included with a total of 4789 patients. Postoperatively, visual field defects improved in 87.0% of patients, stabilized in 12.8% and worsened in 1.0%. Specific protocols regarding timing of surgery were not reported. Only seven studies (16.7%) reported on either the duration of visual symptoms, or diagnostic, or treatment delay. Cohort study 30 NFMA patients (50% female, 60 eyes, mean age 58.5 ± 14.8 years), had a median MD of − 5.3 decibel (IQR − 3.1 to − 10.1). MD was strongly correlated with clinical severity (r = − 0.94, P < 0.0001), and were used for severity of defects cut-off values: (1) normal > − 2 dB, (2) mild − 2 dB to − 4 dB, (3) moderate − 4 to − 8 dB, (4) severe − 8 to − 17 dB, (5) very severe < − 17 dB. Conclusion Surgical decompression is highly effective in improving visual function. Uniform, quantitative grading of visual dysfunction was lacking. MD is a promising quantitative outcome measure. We provide recommendations for the evaluation of timing of surgery, considering severity of visual impairment, which will need further validation based on expert clinical practice.

show abstract

Section: Towards Clinical Benchmarking For Nfma Patients With Optic Chiasm Compressionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quality of care evaluation in non-functioning pituitary adenoma with chiasm compression: visual outcomes and timing of intervention clinical recommendations based on a systematic literature review and cohort study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A total of 15 patients were classified into the non-invasive pituitary tumor group while the other 15 were classified into the invasive adenoma group. Invasive PAs were defined as Hardy–Wilson classification grade III-IV and Knosp classification grades III-IV [ 1 , 2 ] ( Fig. 1 A, Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Pituitary adenomas (PAs) are benign, typically slowly progressing tumors of the adenohypophysis and represent 10–15% of all intracranial tumors, occurring in almost 20% of the general population [ 1 ]. Despite their benign nature, PA often shows invasive growth.…”

Section: Introductionmentioning

confidence: 99%

Differential non-coding RNAs expression profiles of invasive and non-invasive pituitary adenomas

Beylerli

Khasanov

Gareev

et al. 2021

Non-coding RNA Research

View full text Add to dashboard Cite

Background Pituitary adenoma (PA) accounts for 10–15% of all intracranial neoplasms. Despite their benign nature, PA often shows invasive growth. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are a class of non-coding RNAs that play important roles in PA initiation and progression. Aim The aim of this study was to find specific profiles of miR-200a and long non-coding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) in PA based on a comparative study using Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) analyses of tumor tissue and plasma. Methods Plasma and PA tissue samples were obtained from two groups of included patients (15 invasive and 15 non-invasive PA). In addition, plasma samples from patients with invasive PA have collected pre- and post-operation. Plasma and tissue samples subjected to qRT-PCR analyses for the expression levels of miR-200a and lncRNA ANRIL. Results The expression levels of miR-200a and lncRNA ANRIL were increased in tissue samples patients with invasive PA than in the patients with non-invasive PA. In addition, the expression levels of circulating miR-200a and lncRNA ANRIL were increased in patients with invasive PA than in patients with non-invasive PA in the pre-operation period. However, the expression level of plasma circulating miR-200a and lncRNA ANRIL was decreased in patients with invasive PA in the post-operation period. Our results depicted a miR-200a and lncRNA ANRIL expression in tissue and plasma samples in the patients with invasive PA. In addition, Receiver Operating Characteristic (ROC) curve was used to evaluate the diagnostic value of these circulating miR-200a and lncRNA ANRIL. Conclusion The expression of these tumor-associated ncRNAs has been elevated in the PAs. Therefore, miR-200a and lncRNA ANRIL represents as biomarkers for diagnosis and potential targets for novel invasive PA treatment strategies.

show abstract

“…A sintomatologia pode ser derivada da produção hormonal ou dos efeitos de massa intracraniana. (LITHGOW et al, 2019).…”

Section: Tumores Hipofisáriosunclassified

Amenorreia secundária: revisão das etiologias / Secondary amenorrhea: etiologies review

Valadão¹,

Tostes²,

Menezes³

et al. 2022

BJDV

View full text Add to dashboard Cite

Introdução: amenorreia consiste na ausência de menstruação, sendo indicativo de uma disfunção no eixo hipotalâmico-hipofisário-ovariano-uterino em mulheres na menacme, não gestantes/lactantes e que não estejam em uso de medicamento hormonal. Classifica-se em primária ou secundária de acordo com a presença ou não da menarca e com o desenvolvimento de caracteres sexuais secundários. Objetivo: coletar informações da literatura sobre as etiologias da amenorreia secundária, sua propedêutica e terapêutica. Método: trata-se de uma revisão bibliográfica, em que foram selecionados livros e artigos da literatura mundial, obtidos nas bases de dados Scielo, Pubmed, e UpToDate, publicados entre 2015-2021, com Qualis superior a B3 ou fator de impacto superior a 1,5. Foram excluídos revisões de literatura do tema tratado nesse artigo. Desenvolvimento: amenorreia secundária é um sintoma prevalente na população e possui vários diagnósticos etiológicos. Podendo ser derivados de: disfunções no complexo controle hormonal do ciclo menstrual ou alterações anatômicas. Dada a complexidade, frequentemente, necessita de investigação elaborada. A determinação da etiologia é importante porque permite estipular o plano terapêutico apropriado. Conclusão: a investigação e tratamento da amenorreia pode demandar uma equipe multiprofissional envolvida. É preciso educar as pacientes a respeito da sua condição e possíveis prejuízos a saúde em longo prazo. Mesmo que trabalhoso é importante tratar a causa base da amenorreia ainda que não seja uma queixa importante para a paciente.

show abstract

MANAGEMENT OF ENDOCRINE DISEASE: Visual morbidity in patients with pituitary adenoma

Cited by 21 publications

References 86 publications

Quality of care evaluation in non-functioning pituitary adenoma with chiasm compression: visual outcomes and timing of intervention clinical recommendations based on a systematic literature review and cohort study

Quality of care evaluation in non-functioning pituitary adenoma with chiasm compression: visual outcomes and timing of intervention clinical recommendations based on a systematic literature review and cohort study

Differential non-coding RNAs expression profiles of invasive and non-invasive pituitary adenomas

Amenorreia secundária: revisão das etiologias / Secondary amenorrhea: etiologies review

Contact Info

Product

Resources

About