Management of Breast Cancer During Pregnancy Using a Standardized Protocol

Berry, David L.; Theriault, Richard L.; Holmes, Frankie A.; Parisi, Valerie M.; Booser, Daniel J.; Singletary, S. Eva; Buzdar, Aman U.; Hortobágyi, Gabriel N.

doi:10.1097/00006254-199910000-00005

Cited by 64 publications

(135 citation statements)

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“…Although all chemotherapy agents used in the treatment of breast cancer in pregnancy are Category D (ie, teratogenic effects have occurred in people), a surprising safety profile has been demonstrated if administered outside of the first trimester [4,7,11,[56][57][58][59][60][61][62]. Most frequently documented complications included preterm delivery, low birth weight, transient leukopenia of the newborn, and intrauterine growth restriction.…”

Section: Systemic Therapymentioning

confidence: 99%

“…Anderson Cancer Center. In 1999 Berry and colleagues [56] evaluated the treatment of pregnancy-associated breast cancer with 5-Fluorouracil, Doxorubicin, and Cyclophosphamide (FAC: 500 mg/m 2 5-fluorouracil days 1 þ 4; 50 mg/m 2 continuous 72-hour infusion of Doxorubicin days 1 through3; 500 mg/m 2 Cyclophosphamide day 1 of a 3-week cycle). This group reported no antepartum complications temporally attributed to systemic therapy and supported that Apgar scores, birth weights, and immediate postpartum health were normal for all children.…”

Section: Systemic Therapymentioning

confidence: 99%

“…Finally, one child was born with Down syndrome. Only 2 of the 18 school-aged children required special attention at school, and the rest were thought to exhibit normal development [56].…”

Section: Systemic Therapymentioning

confidence: 99%

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Pregnancy-Associated Breast Cancer: A Literature Review

Barnes

Newman

2007

Surgical Clinics of North America

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Breast cancer, along with cervical cancer, is one of the most commonly diagnosed cancers of pregnancy. Most would define gestational breast cancer as breast cancer that is diagnosed during pregnancy, lactation, and up to 12 months post-partum. The diagnostic and therapeutic implications in this clinical setting are special. These women typically present with a more advanced-stage disease that carries an associated poorer prognosis. Physicians thus are challenged to balance aggressive maternal care with appropriate modifications that will ensure fetal protection. . Of women diagnosed with breast cancer younger than 40 years, only approximately 10% will be pregnant [2,3]. These data certainly suggest a low incidence of pregnancy-associated breast cancer. In fact, historically, the incidence is estimated at 1 in 3000 pregnancies [4][5][6]. Despite the overall low incidence, however, gestational breast cancer is one of the most common pregnancy-associated malignancies, second only to cervical cancer [4,6]. Notably, many have offered that this incidence will only increase as more women delay childbearing until later in life [4,7]. This concern is based on the fact that pregnancy-associated breast cancer is age-related, and women

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Section: Systemic Therapymentioning

confidence: 99%

Section: Systemic Therapymentioning

confidence: 99%

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Pregnancy-Associated Breast Cancer: A Literature Review

Barnes

Newman

2007

Surgical Clinics of North America

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“…Thus, no population-based cohort study of birth outcome in women diagnosed with breast cancer before pregnancy has been published. Cohorts without control groups including between four and 121 women (Ribeiro et al, 1986;Daly and Donnellan, 1992;Berry et al, 1999;Giacalone et al, 1999;Kuerer et al, 2002;Ring et al, 2005) have shown that the majority of women who are diagnosed with breast cancer during or shortly after pregnancy give birth to healthy children. Two controlled studies, however, suggested an increased risk of preterm birth and low birth weight for offspring of these women (Zemlickis et al, 1992;Smith et al, 2001).…”

mentioning

confidence: 99%

Birth outcome in women with breast cancer

et al. 2005

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We investigated whether maternal breast cancer affects birth outcome in a nationwide cohort study of 695 births from 1973 to 2002 of women with breast cancer with respect to preterm birth, low birth weight at term, stillbirth and congenital abnormalities as well as mean birth weight, compared with the outcomes of 33 443 births from unaffected mothers. There was no excess risk of adverse birth outcome for the 216 newborns of women with breast cancer before pregnancy. Stratification by mother's treatment did not change the results. For 37 newborns of women diagnosed during pregnancy, the prevalence ratio (PR) of preterm birth was 8.1 (95% confidence interval (CI): 3.8 -17). However, 10 of the 12 preterm deliveries among these women were elective early deliveries. Among 442 births of women diagnosed in the 2 years from time of delivery, the PR of preterm birth was 1.4 (95% CI: 1.0 -2.0), and the PR of low birth weight at term for boys was 2.9 (95% CI: 1.3 -6.3). Overall, our results are reassuring regarding the risks of adverse birth outcome for breast cancer patients.

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“…A study published in 1999 indicated that breast cancer accounts for 0.2% to 3.8% of all cancers affecting women during pregnancy, with a ratio from 1/3,000 to 1/10,000 pregnancies (4) . Another study reported that depending on the country, some case series presented an association of 1/2,000 pregnancies (5) .…”

Section: According To Estimates Published By the Brazilianmentioning

confidence: 99%

Prognosis of breast cancer during pregnancy: evidence for nursing care

Fernandes

Santos²,

Silva

et al. 2011

Rev. Latino-Am. Enfermagem

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This integrative review analyzed evidence available in the literature concerning the prognosis of breast cancer during pregnancy. The following databases were used for selecting studies:PubMed, CINAHL and LILACS. A total of 240 primary studies were identified; 13 papers were included in the integrative review's sample after reading the titles and abstracts and according to the established inclusion and exclusion criteria. There is evidence indicating that pregnancy does not worsen the evolution of breast cancer and a poor prognosis is related to late stage tumors. Among the gaps identified in the studied theme, the need for further studies addressing nursing care provided to pregnant women with breast cancer is highlighted in order to promote improved care in the context of health care. após a leitura dos títulos e resumos e, frente aos critérios de inclusão e exclusão estabelecidos, 13 artigos foram incluídos na amostra da revisão integrativa. Na síntese do conhecimento produzido, há evidências que indicam que a gestação não piora a evolução do câncer de mama e o mau prognóstico está relacionado ao estadiamento tardio do tumor. Dentre as lacunas identificadas, sobre o tópico investigado, destaca-se a necessidade de condução de estudos direcionados para a assistência de enfermagem, prestada à mulher grávida, com câncer de mama, para promover a melhoria do cuidado no contexto da atenção à saúde.Descritores: Neoplasias da Mama; Gravidez; Prognóstico; Enfermagem. El pronóstico de cáncer de mama en el embarazo: evidencias para la atención de enfermeríaEsta revisión integradora de la literatura objetivó analizar las evidencias disponibles en la literatura sobre el pronóstico del cáncer de mama durante el embarazo. La selección de los estudios primarios fue realizada en las bases de datos PubMed, CINAHL y LILACS; se identificaron 240 estudios primarios. Después de la lectura de los títulos y resúmenes y establecimiento de los criterios de inclusión y exclusión, 13 artículos fueron incluidos en la muestra de la revisión integradora. En la síntesis del conocimiento producido hay evidencias que indican que el embarazo no empeora la evolución del cáncer de mama y el pronóstico malo está relacionado con la estadificación clínica tardía del tumor. Entre las lagunas en el tópico investigado hay que resaltar la necesidad de realizar estudios sobre la atención de enfermería prestada a mujeres embarazadas con cáncer de mama para mejoría del cuidado en el contexto de la atención a la salud.

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Management of Breast Cancer During Pregnancy Using a Standardized Protocol

Cited by 64 publications

References 0 publications

Pregnancy-Associated Breast Cancer: A Literature Review

Pregnancy-Associated Breast Cancer: A Literature Review

Birth outcome in women with breast cancer

Prognosis of breast cancer during pregnancy: evidence for nursing care

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