Management of agitation, aggression, and psychosis associated with dementia: A pooled analysis including three randomized, placebo-controlled double-blind trials in nursing home residents treated with risperidone

Deyn, Peter Paul De; Katz, Ira R.; Brodaty, Henry; Lyons, Benjamin; Greenspan, Andrew; Burns, Alistair

doi:10.1016/j.clineuro.2005.03.013

Cited by 93 publications

(115 citation statements)

References 23 publications

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“…In this analysis, we used the third quartile of the total CMAI score in our group as a cutoff. This value, 50, was also in the range of those found in clinical studies (Brodaty and Low, 2003;De Deyn et al, 2005).…”

Section: Discussionsupporting

confidence: 70%

Actigraphic measurement of agitated behaviour in dementia

Nagels

Engelborghs

Vloeberghs

et al. 2006

Int. J. Geriat. Psychiatry

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Section: Discussionsupporting

confidence: 70%

Actigraphic measurement of agitated behaviour in dementia

Nagels

Engelborghs

Vloeberghs

et al. 2006

Int. J. Geriat. Psychiatry

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“…In a meta-analysis by Schneider (1996), antipsychotics proved only 18% more effective than placebo tablets which alone were associated with an average percentage improvement of 37%. While a meta-analysis of risperidone showed it to be effective (De Deyn et al, 2005), a recent large RCT of three atypical antipsychotics in "real world" conditions proved disappointing (Schneider et al, 2006). Even combinations of carefully tailored nursing, psychosocial and medical interventions resulted in relatively modest, though statistically significant, changes in behavior in a nursing trial by Opie et al (2002) in which counts of restlessness and verbal disruption fell by 26% and 20% respectively.…”

Section: Discussionmentioning

confidence: 99%

Psychosocial treatments of behavior symptoms in dementia: a systematic review of reports meeting quality standards

O'Connor

Ames

Gardner

et al. 2008

IPG

174

147

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Objective: To provide a systematic review of selected experimental studies of psychosocial treatments of behavioral disturbances in dementia. Psychosocial treatments are defined here as strategies derived from one of three psychologically oriented paradigms (learning theory, unmet needs and altered stress thresholds).Method: English language reports published or in press by December 2006 were identified by means of database searches, checks of previous reviews and contact with recognized experts. Papers were appraised with respect to study design, participants' characteristics and reporting details. Because people with dementia often respond positively to personal contact, studies were included only if control conditions entailed similar levels of social attention or if one treatment was compared with another.Results: Only 25 of 118 relevant studies met every specification. Treatment proved more effective than an attention control condition in reducing behavioral symptoms in only 11 of the 25 studies. Effect sizes were mostly small or moderate. Treatments with moderate or large effect sizes included aromatherapy, abilityfocused carer education, bed baths, preferred music and muscle relaxation training.Conclusions: Some psychosocial interventions appear to have specific therapeutic properties, over and above those due to the benefits of participating in a clinical trial. Their effects were mostly small to moderate with a short duration of action. This limited action means that treatments will work best in specific, timelimited situations. In the few studies that addressed within-group differences, there were marked variations in response. Some participants benefited greatly from a treatment, while others did not. Interventions proved more effective when tailored to individuals' preferences.

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“…Aunque hay poca evidencia en la literatura actual sobre la eficacia, seguridad y tolerabilidad de las intervenciones farmacológicas para la demencia en adultos con DI, el tratamiento de la demencia debería implicar un abordaje tanto farmacológico como no farmacológico (Moran et al, 2013), debiendo incluir el farmacológico medicamentos que reduzcan la progresión del deterioro cognitivo, métodos de neuroprotección y la curación de la enfermedad, así como fármacos que sirvan de ayuda para las conductas anómalas afectivas y/o psicóticas, como por ejemplo, la Risperidona, un fármaco antipsicótico que ha demostrado reducir significativamente la agitación, agresión y los síntomas asociados a la psicosis en personas de la población general con EA (De Deyn et al, 2005;Rabinowitz et al, 2007).…”

Section: Discussionunclassified

Síndrome de Down y enfermedad de Alzheimer: factores de riesgo, evaluación e intervención

Pérez

Gómez

Rodríguez

2016

Redis

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Existe una estrecha relación entre el síndrome de Down y la enfermedad de Alzheimer. Diversos factores de riesgo influyen en esta relación, en la que la evaluación de la demencia es difícil debido a la falta de instrumentos y tratamientos específicos. Se realizó una búsqueda de los años comprendidos entre 2005-2015 en diferentes bases de datos. Se identificaron diversos factores de riesgo (genéticos, ambientales, cognitivos) y se encontraron varios instrumentos de evaluación, poco adecuados y/o con debilidades psicométricas. Los tratamientos existentes son escasos y, casi exclusivamente, farmacológicos. Se discute acerca de la importancia de llevar a cabo estudios sistemáticos sobre los factores de riesgo para la prevención de la enfermedad de Alzheimer en personas con síndrome de Down, así como la necesidad de un protocolo de evaluación específico y adaptado que permita implementar tratamientos más específicos y efectivos.

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Management of agitation, aggression, and psychosis associated with dementia: A pooled analysis including three randomized, placebo-controlled double-blind trials in nursing home residents treated with risperidone

Cited by 93 publications

References 23 publications

Actigraphic measurement of agitated behaviour in dementia

Actigraphic measurement of agitated behaviour in dementia

Psychosocial treatments of behavior symptoms in dementia: a systematic review of reports meeting quality standards

Síndrome de Down y enfermedad de Alzheimer: factores de riesgo, evaluación e intervención

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