Management of a Patient with Refractory Idiopathic Thrombocytopenic Purpura

Taylor, J. Andrew; Rickey, Ashley; Johnson, Crystal; Connor, Chelsea; Pullatt, Rana

doi:10.1177/000313481608200301

Cited by 1 publication

(1 citation statement)

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“…Moreover, immunoglobulin therapy, splenectomy, splenic embolization, immunosuppression and traditional Chinese medicine are optional methods ( 2 ). The overall effective treatment rate is 75–85%, with a recurrence rate of 20–35% ( 3 ). Clinical treatment is classified as three types; initial treatment, retreatment, and the intractable stage.…”

Section: Introductionmentioning

confidence: 99%

Analysis of clinical effects and mechanism of recombinant human interleukin-11 with glucocorticoids for treatment of idiopathic thrombocytopenic purpura

Wang

Sun

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the present study was to evaluate the effectiveness and safety of recombinant human interleukin-11 (IL-11) with glucocorticoids for treatment of adult idiopathic thrombocytopenic purpura (ITP) and the regulatory effect on immune mechanisms. A total of 80 patients with initial diagnosis of ITP admitted to our hospital were selected. Patients were randomly divided into the control group and observation group, with 40 cases each. The control group received glucocorticoids treatment, and the observation group received IL-11 and glucocorticoids. The treatment effects were compared. The total effective rate and effective degree of the observation group was higher than in the control group and the difference was statistically significant (P<0.05); comparing the incidence of complications of the two groups, there was no statistical difference (P>0.05). In the observation group, onset time was reduced, platelet recovery level increased and platelet antibody positive rate decreased, and the differences were statistically significant (P<0.05). The total treatment course was shorter and recurrence rate was lower in the observation group compared with the control group, and the differences were statistically significant (P<0.05). The percentage of CD4+CD25+ regulatory T cells decreased in the two groups after treatment, and was more pronounced in the observation group. The difference was statistically significant (P<0.05). In conclusion, IL-11 with glucocorticoids for the treatment of adult ITP is safe and effective, and may be associated with decreased percentage of CD4+CD25+ regulatory T cells.

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Section: Introductionmentioning

confidence: 99%