Mammalian Satellite DNA

Enukashvily, N. I.; Ponomartsev, N. V.

doi:10.1016/b978-0-12-410523-2.00002-x

Cited by 43 publications

(48 citation statements)

References 154 publications

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“…Emerging contribution to centromere structure and function have been indicated as one of the main roles of (peri)centromeric satDNAs, which could be associated with kinetochore formation, spindle microtubule attachment, and sister chromatid cohesion (e.g., Guenatri et al 2004;Wong et al 2007;Hall et al 2012;Enukashvily and Ponomartsev 2013;Plohl et al 2014). Lately, satDNAs have also been implicated in the occurrence of chromosomal rearrangements, and consequently in the evolution of genomes, due to their high molecular dynamics (e.g., Adega et al 2009;Zhu et al 2011;Hall et al 2012).…”

Section: Introductionmentioning

confidence: 98%

“…Despite initially considered useless genomic elements (Ohno 1972), the repetitive sequences are presently seen as an important fraction of the eukaryotic genome to which several functions have been ascribed (e.g., Richard et al 2008;Hall et al 2012;Rebollo et al 2012;Enukashvily and Ponomartsev 2013;Plohl et al 2014). Emerging contribution to centromere structure and function have been indicated as one of the main roles of (peri)centromeric satDNAs, which could be associated with kinetochore formation, spindle microtubule attachment, and sister chromatid cohesion (e.g., Guenatri et al 2004;Wong et al 2007;Hall et al 2012;Enukashvily and Ponomartsev 2013;Plohl et al 2014).…”

Section: Introductionmentioning

confidence: 98%

“…The more commonly repetitive sequences found within these heterochromatic blocks are the highly tandemly repeated sequences, satellite DNAs (satDNAs) (Enukashvily and Ponomartsev 2013;Vittorazzi et al 2014). These can exhibit several millions of copies in a genome, organized into long arrays (e.g., Adega et al 2009;Plohl 2010), being preferentially located in or around centromeres (e.g., Plohl et al 2014), or eventually assume an interstitial and/or terminal location (e.g., Santos et al 2004;Louzada et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…A significant portion of eukaryotic genomes is comprised by repetitive DNA sequences, mainly located at the densely packed heterochromatic regions of the chromosomes (e.g., Enukashvily and Ponomartsev 2013). The more commonly repetitive sequences found within these heterochromatic blocks are the highly tandemly repeated sequences, satellite DNAs (satDNAs) (Enukashvily and Ponomartsev 2013;Vittorazzi et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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The puzzling character of repetitive DNA in Phodopus genomes (Cricetidae, Rodentia)

et al. 2015

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Three novel repetitive DNA sequences are described, presenting a similar heterochromatic chromosomal location in two hamster species: Phodopus roborovskii and Phodopus sungorus (Cricetidae, Rodentia). Namely, two species-specific repetitive sequences (PROsat from P. roborovskii and PSUchr1sat from P. sungorus) surrounding a third one (PsatDNA), that is shared by both hamster genomes. Fiber-FISH analyses revealed that PROsat intermingles with PsatDNA in P. roborovskii and PSUchr1sat intermingles with PsatDNA in P. sungorus. A model explaining the evolution of this intricate chromosomal distribution is proposed, which can explain better the evolution of these very derivative genomes (in comparison to the ancestral Muroidea). The most plausible evolutionary scenario seems to be the expansion of a number of repeats into other's domain, most probably resulting in its intermingling, followed by the subsequent spread of these complex repeats from a single chromosomal location to other chromosomes. Evidences of an association between repetitive sequences and the chromosome evolution process were observed, namely for PROsat. Most probably, the evolutionary breakpoints that shaped PRO and PSU chromosomes (pericentric inversions and fusions) occurred within the boundaries of PROsat blocks in the ancestor. The repeats high diversity at the heterochromatic regions of Phodopus chromosomes, together with its complex organization, suggests that these species are important models for evolutionary studies, namely in the investigation of a possible relationship between repetitive sequences and the occurrence of chromosomal rearrangements and consequently, in genome evolution.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The puzzling character of repetitive DNA in Phodopus genomes (Cricetidae, Rodentia)

et al. 2015

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“…However, at least four main types can be described: one active and three repressive types (Ciabrelli and Cavalli 2015). Further, whereas heterochromatin was thought to be transcriptionally inert and euchromatin transcriptionally active, we now know that this distinction is not absolute-some transcription can occur in the heterochromatin (reviewed in Enukashvily and Ponomartsev 2013;Hall et al 2012;Saksouk et al 2015). Together, these new findings emphasize the fact that there is no simple distinction between two types of chromatin-heterochromatin and euchromatin-and therefore no clear correlation exists between a particular higher order chromatin structure and one of these chromatin types.…”

Section: Higher Order Chromatin Structure and Organizationmentioning

confidence: 97%

Coming to terms with chromatin structure

et al. 2015

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Chromatin, once thought to serve only as a means to package DNA, is now recognized as a major regulator of gene activity. As a result of the wide range of methods used to describe the numerous levels of chromatin organization, the terminology that has emerged to describe these organizational states is often imprecise and sometimes misleading. In this review, we discuss our current understanding of chromatin architecture and propose terms to describe the various biochemical and structural states of chromatin.

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Characterization of a satellite DNA in the genera Lacerta and Timon (Reptilia, Lacertidae) and its role in the differentiation of the W chromosome

et al. 2018

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In this study, IMO-TaqI satDNA, previously isolated in several species of Lacertidae, was isolated and characterized from four species of the genus Lacerta and three of the genus Timon. The aim was to gain further insights into the evolutionary dynamics of this satDNA, its occurrence among lacertids and to understand if it plays any role in sex chromosome evolution in these seven species. The results here obtained highlighted the presence of this repetitive element in the genome of all the species investigated, thus indicating that IMO-TaqI satDNA is evolutionary conserved among a wide variety of lacertids. In addition, this element was found to be very abundant in the constitutive heterochromatin of the W-sex chromosome of the four Lacerta species investigated. The occurrence of IMO-TaqI satDNA on Lacerta heterochromosome suggests that it is involved in the differentiation of the W chromosome by heterochromatinization, and the fact that it is absent in the W of other lacertids investigated seems to confirm that repetitive DNA sequences would remain randomly trapped into the sex chromosomes, undergoing amplification as a consequence of the suppression of recombination.

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Mammalian Satellite DNA

Cited by 43 publications

References 154 publications

The puzzling character of repetitive DNA in Phodopus genomes (Cricetidae, Rodentia)

The puzzling character of repetitive DNA in Phodopus genomes (Cricetidae, Rodentia)

Coming to terms with chromatin structure

Characterization of a satellite DNA in the genera Lacerta and Timon (Reptilia, Lacertidae) and its role in the differentiation of the W chromosome

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