2005
DOI: 10.1590/s0001-37652005000100006
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Abstract: Trypanosoma cruzi, the etiological agent of Chagas' disease, occurs as different strains or isolates that may be grouped in two major phylogenetic lineages: T. cruzi I, associated with the sylvatic cycle and T. cruzi II, linked to the human disease. In the mammalian host the parasite has to invade cells and many studies implicated the flagellated trypomastigotes in this process. Several parasite surface components and some of host cell receptors with which they interact have been identified. Our work focused o… Show more

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Cited by 64 publications
(42 citation statements)
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References 82 publications
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“…This fact suggests that trypomastigotes are susceptible to complement. When the amastigote nest ruptures, undifferentiated amastigote forms with invasive capacity are released as reported by Mortara et al 42 , resulting in the persistence of infection for a long period.…”
Section: Discussionmentioning
confidence: 85%
“…This fact suggests that trypomastigotes are susceptible to complement. When the amastigote nest ruptures, undifferentiated amastigote forms with invasive capacity are released as reported by Mortara et al 42 , resulting in the persistence of infection for a long period.…”
Section: Discussionmentioning
confidence: 85%
“…In four or more days, multiplication ceases; amastigotes briefly acquire epimastigote-like morphology and markers and transform into nondividing infective trypomastigote forms which are cytolytically released from the host cells (1,2,6,26,48). Serial observations of infections of bovine embryo skin and muscle cells have shown that prereplicative lag periods, doubling times of amastigotes, and durations of the entire intracellular cycle varied markedly between the five clones examined (12).…”
Section: Resultsmentioning
confidence: 99%
“…Of particular interest here are the unorthodox molecular and metabolic peculiarities that T. cruzi shares with other kinetoplastids (43) and its elaborate and relatively protracted intracellular life cycle (2,6,26,48). Furthermore, parasite-expressed and -secreted proteases, trans-sialidases, and other effectors have been shown to modulate in vitro and in vivo infection with T. cruzi (e.g., see references 2, 36, and 37).…”
mentioning
confidence: 99%
“…A TcLYT1 Ϫ/Ϫ strain showed diminished infectivity in cell cultures (93) and attenuated virulence in the mouse model (159). The vacuolar escape of T. cruzi may depend on the differentiation of metacyclic trypomastigotes into amastigotes (93,99), as hemolytic activity has been detected for only some developmental stages. A trans-sialidase localized on the surface of T. cruzi trypomastigotes facilitates exit from the PV (120), but it remains uncertain if and how this relates to the action of TcTOX.…”
Section: Vacuole Lysis and Escape To The Cytosolmentioning
confidence: 99%