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Cited by 98 publications
(125 citation statements)
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References 70 publications
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“…Therefore, PEC systems composed of PEI-M are expected to provide an enhanced biocompatibility compared to unmodified PEI. PEI-M systems have been established in the last years as potent carrier systems for model drugs ATP [11,12], si-RNA and DNA [9,13] and show a benign interaction to different relevant cell types [9,10]. Herein, zoledronate (ZOL) was chosen, since it is to date an established BP of choice for the systemic therapy of osteoporosis [14] and multiple myeloma [15], which is more potent compared to PAM.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, PEC systems composed of PEI-M are expected to provide an enhanced biocompatibility compared to unmodified PEI. PEI-M systems have been established in the last years as potent carrier systems for model drugs ATP [11,12], si-RNA and DNA [9,13] and show a benign interaction to different relevant cell types [9,10]. Herein, zoledronate (ZOL) was chosen, since it is to date an established BP of choice for the systemic therapy of osteoporosis [14] and multiple myeloma [15], which is more potent compared to PAM.…”
Section: Introductionmentioning
confidence: 99%
“…Efforts have been made to increase the delivery efficiency of non-viral vectors, including the creation of sophisticated vehicles able to mimic some of the viral properties regarding both size and biological properties [2]. These vectors are called "artificial viruses" and include polymeric constructs [4][5][6], protein-only shells and virus-like particles [4]. Among the properties of these vectors are the ability to condense and protect DNA from nuclease degradation, low systemic and cellular toxicity, membrane crossing abilities, and steady expression of the therapeutic gene [7].…”
Section: Introductionmentioning
confidence: 99%
“…Based on these advantages of HBP different applications have been suggested, for instance possible implementations of HBP are discussed in the field of medicine [1][2][3][4][5][6][7][8], catalysis [9][10][11][12][13], membrane materials [14][15][16][17][18][19][20], chemical engineering [21][22][23][24], sensors [25][26][27][28], thermosets [29][30][31] or as rheological modifier [32,33]. Polymeric drug delivery systems offer great opportunities to effectively control the drug release in human body [34][35][36][37][38][39][40][41][42][43][44]. In addition dendrimers can be surface engineered to release the drug at desired site, that is, as targeted drug delivery.…”
Section: Introductionmentioning
confidence: 99%