Maltodextrins as new chiral selectors in the design of potentiometric, enantioselective membrane electrodes

Abstract

Maltodextrins (dextrose equivalent (DE) 4.0-7.0, 13.0-17.0, and 16.5-19.5) are proposed as novel chiral selectors for the construction of potentiometric, enantioselective membrane electrodes. The potentiometric, enantioselective membrane electrodes can be used reliably for the assay of S-captopril as raw material and in pharmaceutical formulations such as Novocaptopril tablets, by use of direct potentiometry. The best response was obtained when maltodextrin with higher DE was used for construction of the electrode. The best enantioselectivity and time-stability was achieved for the lower DE maltodextrin. L-proline was found to be the main interferent for all the proposed electrodes. The surface of the electrodes can be regenerated by simply polishing; this furnishes a fresh surface ready for use in a new assay.

Enantioselective Electrochemical Sensors

“…The most commonly utilized chiral selectors for potentiometric, enantioselective membrane electrode (PEME) construction include crown ethers [16][17][18][19], cyclodextrins [5,20], maltodextrins [21], and quinine and quinidine derivatives (unpublished data). The response characteristics of these sensors and their enantioselectivity are correlated with the type of matrix used for sensor construction.…”

“…Maltodextrins (dextrose equivalent (DE) 4-7, 13-17, and 16.5-19.5) have been proposed as novel chiral selectors for the construction of potentiometric, enantioselective membrane electrodes for (S)-captopril assay [21]. The potentiometric, enantioselective membrane electrodes can be used reliably for the assay of (S)-captopril as raw material and from pharmaceutical formulations such as Novocaptopril tablets, using direct potentiometry.…”

The Current Usage of Selectivity Coefficients for the Characterization of Ion‐Selective Electrodes. A Critical Survey of the 2000/2001 Literature

“…This procedure has been recently chosen for experimental investigation of selectivity theories [57,58] as well as for extensive interferant screening [59].…”

Enantioanalysis of glyceric acid using enantioselective, potentiometric membrane electrodes: applications for the diagnosis of PH II and -glyceric acidemia/acidurias

“…Enantioselective, potentiometric membrane electrodes (EPMEs) based on chiral selectors had been developed for enantiomeric assay. Cyclodextrins [19,20], macrocyclic antibiotics [21], and maltodextrins [22] were used as chiral selectors for enantiomers determination. Maltodextrins have been used as host-complexing agents in enantiomer recognition [23,24].…”