Malondialdehyde concentrations in obsessive–compulsive disorder: a systematic review and meta-analysis

Abstract

Background This meta-analysis aimed to investigate serum and plasma malondialdehyde (MDA) levels in patients with obsessive–compulsive disorder (OCD) in comparison to healthy controls. Methods Following the PRISMA protocol, we searched for the relevant studies through the databases of Scopus, PubMed, Google Scholar, and web of science until September 2019 with no time restriction. Overall, nine studies were included in the current meta-analysis. Data were pooled using a random-effects model; in addition, standard mean difference (SMD) and/or weight mean difference (WMD) was calculated. Cochran’s Q test and I-square (I2) statistics were used to evaluate between-study heterogeneity. The Newcastle–Ottawa scale (NOS) was used to evaluate the quality of the included studies. Statistical analyses were done using the STATA version 14. Results Our systematic review included nine case–control studies (including 367 cases and 337 controls). Pooling findings from these studies showed a significantly higher MDA level in OCD patient compared to control groups (SMD = 1.62; 95% CI [0.53, 2.72]; I2 = 96.9%; Pheterogeneity (Ph) < 0.001). This finding remained unchanged among studies which reported MDA in the same unit (WMD = 1.93; 95% CI [0.27, 3.59]; I2 = 99.2%; Ph < 0.001). Subgroup analysis by the study location and sample size revealed findings that were also significant. Conclusion We found that MDA levels are higher in OCD patients than healthy controls. This finding highlights the importance of inflammatory responses in OCD patients that should be considered for future investigations. Further studies are recommended to expand current knowledge on this issue.

The Oxidative Status and Na+/K+-ATPase Activity in Obsessive-Compulsive Disorder: A Case Control Study

“…Also, patients with OCD had lower ATPase activity compared to healthy controls. Some case control studies [36][37][38][39][40][41][42][43] and a metaanalysis [44] concentrated on the relationship between OCD and MDA. In contrast with our study, Ranjekar et al [45] observed no significant differences in serum levels of lipid peroxidation markers between patients with schizophrenic and healthy control, and R. Kurup and P. Kurup [46] found that OCD patients had lower MDA level than controls.…”

Potential biomarkers and therapeutic targets for obsessive compulsive disorder

“…Increased MDA concentrations in peripheral blood samples has been proposed as a biochemical biomarker for the diagnosis and evaluation of the severity of the symptoms of OCD in several independent studies ( 48 - 52 ). A recent meta-analysis indicated that serum/plasma concentrations of MDA are positively correlated OCD pathology in human subjects ( 53 ). Such systemic redox imbalances have also been proposed by another independent meta-analytical study, wherein the authors reported significant positive association of oxidative damage markers such as 8-hydroxydeoxyguanosine (8-OHdG) and MDA, in addition to a negative correlation of endogenous antioxidant systems ( e.g.…”